Bringing cohort studies to the bedside: framework for a 'green button' to support clinical decision-making

Blanca Gallego, Scott R. Walter, Richard O. Day, Adam G. Dunn, Vijay Sivaraman, Nigam Shah, Christopher A. Longhurst, Enrico Coiera

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

When providing care, clinicians are expected to take note of clinical practice guidelines, which offer recommendations based on the available evidence. However, guidelines may not apply to individual patients with comorbidities, as they are typically excluded from clinical trials. Guidelines also tend not to provide relevant evidence on risks, secondary effects and long-term outcomes. Querying the electronic health records of similar patients may for many provide an alternate source of evidence to inform decision-making. It is important to develop methods to support these personalized observational studies at the point-of-care, to understand when these methods may provide valid results, and to validate and integrate these findings with those from clinical trials.

LanguageEnglish
Pages191-197
Number of pages7
JournalJournal of Comparative Effectiveness Research
Volume4
Issue number3
DOIs
Publication statusPublished - 1 May 2015

Fingerprint

Cohort Studies
Point-of-Care Systems
Clinical Trials
Guidelines
Electronic Health Records
Practice Guidelines
Observational Studies
Comorbidity
Decision Making
Clinical Decision-Making

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • cohort studies
  • comparative effectiveness
  • electronic health records
  • personalized prognosis

Cite this

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abstract = "When providing care, clinicians are expected to take note of clinical practice guidelines, which offer recommendations based on the available evidence. However, guidelines may not apply to individual patients with comorbidities, as they are typically excluded from clinical trials. Guidelines also tend not to provide relevant evidence on risks, secondary effects and long-term outcomes. Querying the electronic health records of similar patients may for many provide an alternate source of evidence to inform decision-making. It is important to develop methods to support these personalized observational studies at the point-of-care, to understand when these methods may provide valid results, and to validate and integrate these findings with those from clinical trials.",
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Bringing cohort studies to the bedside : framework for a 'green button' to support clinical decision-making. / Gallego, Blanca; Walter, Scott R.; Day, Richard O.; Dunn, Adam G.; Sivaraman, Vijay; Shah, Nigam; Longhurst, Christopher A.; Coiera, Enrico.

In: Journal of Comparative Effectiveness Research, Vol. 4, No. 3, 01.05.2015, p. 191-197.

Research output: Contribution to journalReview articleResearchpeer-review

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AU - Day, Richard O.

AU - Dunn, Adam G.

AU - Sivaraman, Vijay

AU - Shah, Nigam

AU - Longhurst, Christopher A.

AU - Coiera, Enrico

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