Burgeoning polymer nano blends for improved controlled drug release: a review

Saeid Maghsoudi, Bahareh Taghavi Shahraki, Navid Rabiee, Yousef Fatahi, Rassoul Dinarvand, Maryam Tavakolizadeh, Sepideh Ahmadi, Mohammad Rabiee, Mojtaba Bagherzadeh, Ali Pourjavadi, Hassan Farhadnejad, Mohammadreza Tahriri*, Thomas J. Webster, Lobat Tayebi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)
1 Downloads (Pure)

Abstract

With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.

Original languageEnglish
Pages (from-to)4363-4392
Number of pages30
JournalInternational Journal of Nanomedicine
Volume15
DOIs
Publication statusPublished - 2020
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • polymer blends
  • drug delivery
  • wound dressing
  • PLGA
  • chitosan
  • starch

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