Abstract
Injection of muscimol in the caudal ventrolateral medulla increases blood pressure and stimulates neuronal c-fos expression in the rostral ventral medulla (RVM). The blockade of c-fos expression in the RVM by antisense oligonucleotides attenuates the blood pressure response to this muscimol-induced disinhibition of the RVM and also reduces resting blood pressure. The results suggest that cardiovascular neurons in the RVM express c-fos and that the basal and stimulated expression of the c-fos gene is important in the central regulation of blood pressure.
Original language | English |
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Pages (from-to) | 67-79 |
Number of pages | 13 |
Journal | Clinical and Experimental Hypertension |
Volume | 17 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 1995 |
Keywords
- Antisense oligonucleotides
- Blood pressure
- Fos
- Rostral ventral medulla