C-FOS expression in central cardiovascular pathways

J. B. Minson; S. Suzuki; I. J. Llewellyn-Smith; P. M. Pilowsky; L. F. Arnolda; J. P. Chalmers

doi:10.3109/10641969509087055

C-FOS expression in central cardiovascular pathways

J. B. Minson^*, S. Suzuki, I. J. Llewellyn-Smith, P. M. Pilowsky, L. F. Arnolda, J. P. Chalmers

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Injection of muscimol in the caudal ventrolateral medulla increases blood pressure and stimulates neuronal c-fos expression in the rostral ventral medulla (RVM). The blockade of c-fos expression in the RVM by antisense oligonucleotides attenuates the blood pressure response to this muscimol-induced disinhibition of the RVM and also reduces resting blood pressure. The results suggest that cardiovascular neurons in the RVM express c-fos and that the basal and stimulated expression of the c-fos gene is important in the central regulation of blood pressure.

Original language	English
Pages (from-to)	67-79
Number of pages	13
Journal	Clinical and Experimental Hypertension
Volume	17
Issue number	1-2
DOIs	https://doi.org/10.3109/10641969509087055
Publication status	Published - 1995

Keywords

Antisense oligonucleotides
Blood pressure
Fos
Rostral ventral medulla

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title = "C-FOS expression in central cardiovascular pathways",

abstract = "Injection of muscimol in the caudal ventrolateral medulla increases blood pressure and stimulates neuronal c-fos expression in the rostral ventral medulla (RVM). The blockade of c-fos expression in the RVM by antisense oligonucleotides attenuates the blood pressure response to this muscimol-induced disinhibition of the RVM and also reduces resting blood pressure. The results suggest that cardiovascular neurons in the RVM express c-fos and that the basal and stimulated expression of the c-fos gene is important in the central regulation of blood pressure.",

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AU - Minson, J. B.

AU - Suzuki, S.

AU - Llewellyn-Smith, I. J.

AU - Pilowsky, P. M.

AU - Arnolda, L. F.

AU - Chalmers, J. P.

PY - 1995

Y1 - 1995

N2 - Injection of muscimol in the caudal ventrolateral medulla increases blood pressure and stimulates neuronal c-fos expression in the rostral ventral medulla (RVM). The blockade of c-fos expression in the RVM by antisense oligonucleotides attenuates the blood pressure response to this muscimol-induced disinhibition of the RVM and also reduces resting blood pressure. The results suggest that cardiovascular neurons in the RVM express c-fos and that the basal and stimulated expression of the c-fos gene is important in the central regulation of blood pressure.

AB - Injection of muscimol in the caudal ventrolateral medulla increases blood pressure and stimulates neuronal c-fos expression in the rostral ventral medulla (RVM). The blockade of c-fos expression in the RVM by antisense oligonucleotides attenuates the blood pressure response to this muscimol-induced disinhibition of the RVM and also reduces resting blood pressure. The results suggest that cardiovascular neurons in the RVM express c-fos and that the basal and stimulated expression of the c-fos gene is important in the central regulation of blood pressure.

KW - Antisense oligonucleotides

KW - Blood pressure

KW - Fos

KW - Rostral ventral medulla

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SP - 67

EP - 79

JO - Clinical and Experimental Hypertension

JF - Clinical and Experimental Hypertension

IS - 1-2

ER -

C-FOS expression in central cardiovascular pathways

Abstract

Keywords

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