TY - JOUR
T1 - Caffeine exposure in utero increases the incidence of apnea in adult rats
AU - Tye, Katrina
AU - Pollard, Irina
AU - Karlsson, Leif
AU - Scheibner, Viera
AU - Tye, Gerry
PY - 1993
Y1 - 1993
N2 - Caffeine abuse during pregnancy may be a factor in the development of long-term breathing abnormalities. Therefore, the objective of the present study was to monitor adult breathing patterns after in utero exposure to caffeine. This was done by isolating episodes of apnea of more than 6-s duration from the breathing data as obtained by the Cotwatch® breathing monitors adapted for rat use. The breathing record obtained over 6 consecutive days was expressed as daily weighted apnea-hypopnea density (WAHD) values. It was shown that administration of caffeine in moderate (30 mg/kg daily) or high (60 mg/kg daily) doses throughout gestation resulted in a significant dose-dependent increase in the WAHD value. The experimental offspring were significantly growth retarded in utero and their subsequent growth rates were also affected. The caffeine-exposed pups grew more slowly with growth plateauing at the same age, resulting in smaller adults. A link was suggested between infants with apnea of prematurity, when occuring after the first week, and an increased risk for later apnea and sudden infant death syndrome.
AB - Caffeine abuse during pregnancy may be a factor in the development of long-term breathing abnormalities. Therefore, the objective of the present study was to monitor adult breathing patterns after in utero exposure to caffeine. This was done by isolating episodes of apnea of more than 6-s duration from the breathing data as obtained by the Cotwatch® breathing monitors adapted for rat use. The breathing record obtained over 6 consecutive days was expressed as daily weighted apnea-hypopnea density (WAHD) values. It was shown that administration of caffeine in moderate (30 mg/kg daily) or high (60 mg/kg daily) doses throughout gestation resulted in a significant dose-dependent increase in the WAHD value. The experimental offspring were significantly growth retarded in utero and their subsequent growth rates were also affected. The caffeine-exposed pups grew more slowly with growth plateauing at the same age, resulting in smaller adults. A link was suggested between infants with apnea of prematurity, when occuring after the first week, and an increased risk for later apnea and sudden infant death syndrome.
KW - apnea
KW - brain differentiation
KW - caffeine
KW - developmental abnormalities
KW - hypopnea
KW - stress
KW - sudden infant death syndrome (SIDS)
KW - xenobiotic agents
UR - http://www.scopus.com/inward/record.url?scp=0027653028&partnerID=8YFLogxK
U2 - 10.1016/0890-6238(93)90089-P
DO - 10.1016/0890-6238(93)90089-P
M3 - Article
C2 - 8274820
AN - SCOPUS:0027653028
SN - 0890-6238
VL - 7
SP - 449
EP - 452
JO - Reproductive Toxicology
JF - Reproductive Toxicology
IS - 5
ER -