Can direct stenting in selected saphenous vein graft lesions be considered an alternative to percutaneous intervention with a distal protection device?

Teruo Okabe, Joseph Lidsay, Rebecca Torguson, Daniel H. Steinberg, Probal Roy, Tina L. Pinto Slottow, Kimberly Kaneshige, Zhenyi Xue, Lowell F. Satler, Kenneth M. Kent, Augusto D. Pichard, Ron Waksman*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    28 Citations (Scopus)

    Abstract

    Background: Distal embolization during percutaneous coronary intervention (PCI) of saphenous vein graft (SVG) lesions is associated with a high rate of myonecrosis. Although direct stenting (DS) is feasible with less catheter manipulations, its ability to prevent distal embolization in SVG lesions compared with distal protection devices (DPD) is unknown. Methods: The study included 188 SVG lesions subjected to PCI, 101 patients with 101 lesions treated with DPD, and 87 patients with 87 lesions by DS without DPD. Major adverse cardiovascular events (MACE) in-hospital and at 30 days were compared. Results: Baseline characteristics were comparable, except for higher frequencies of unstable angina (53% vs. 67%, P = 0.045) and prior myocardial infarction (38% vs. 53%, P = 0.07) in the DS group. There was no difference in lesion type aside from more restenotic lesions in the DS group (7% vs. 16%, P = 0.047). Drug-eluting stent deployment was similar. Stent length in the DPD group (22.8 ± 7.2 mm) was significantly longer than that in the DS group (17.6 ± 8.0 mm, P < 0.001). Although maximum creatine kinase (CK)-MB value in the DPD group (2.5 ± 5.8 ng/ml) was significantly larger than in the DS group (1.3 ± 1.5 ng/ml, P 0.039), the frequency of CK-MB rise >2 times the upper limit of normal did not differ (11% vs. 6%, P = 0.2). There were no differences in MACE rates in-hospital and at 30 days. By multivariate analysis, neither DPD nor DS was a significant predictor for maximum CK-MB value. Conclusion: DS should be considered an alternative treatment to PCI with DPD for selected SVG lesions.

    Original languageEnglish
    Pages (from-to)799-803
    Number of pages5
    JournalCatheterization and Cardiovascular Interventions
    Volume72
    Issue number6
    DOIs
    Publication statusPublished - 15 Nov 2008

    Keywords

    • Direct stenting
    • Distal protection device
    • Saphenous vein graft disease

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