Cancer initiation and progression: An unsimplifiable complexity

Fabio Grizzi*, Antonio Di Ieva, Carlo Russo, Eldo E. Frezza, Everardo Cobos, Pier Carlo Muzzio, Maurizio Chiriva-Internati

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Citations (Scopus)


Background: Cancer remains one of the most complex diseases affecting humans and, despite the impressive advances that have been made in molecular and cell biology, how cancer cells progress through carcinogenesis and acquire their metastatic ability is still widely debated. Conclusion: There is no doubt that human carcinogenesis is a dynamic process that depends on a large number of variables and is regulated at multiple spatial and temporal scales. Viewing cancer as a system that is dynamically complex in time and space will, however, probably reveal more about its underlying behavioural characteristics. It is encouraging that mathematicians, biologists and clinicians continue to contribute together towards a common quantitative understanding of cancer complexity. This way of thinking may further help to clarify concepts, interpret new and old experimental data, indicate alternative experiments and categorize the acquired knowledge on the basis of the similarities and/or shared behaviours of very different tumours.

Original languageEnglish
Article number37
Pages (from-to)1-6
Number of pages6
JournalTheoretical Biology and Medical Modelling
Publication statusPublished - 17 Oct 2006
Externally publishedYes


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