Candidate regions for testicular cancer susceptibility genes: The International Testicular Cancer Linkage Consortium

D. Timothy Bishop*, Elizabeth Rapley, Kathy Tucker, Fellicity Collins, Jenny Donald, Michael Friedlander, Hong Qi Peng, Paul Goss, David Hogg, Douglas F. Easton, Dawn Teare, Gillian Crockford, David Forman, Michael Leahy, Julia G. Bodmer, Jonathon Moses, Susan Tonks, R. Timothy D Oliver, Patrick Biggs, Sheila SealRita Barfoot, Sandra Gill, Sandeep Patel, Rifat Hamoudi, Rachael Hunter, Ian Thomlinson, Colin Cooper, Mike Stratton, Robert Huddart, Sophie D. Fosså, Ketil Heimdal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Although the aetiology of testicular cancer is unknown, a clear familial component has been identified in a number of studies. In an effort to identify susceptibility genes for testicular cancer, the International Testis Cancer Linkage Consortium has been collecting families with multiple cases of testicular cancer. These families have been genotyped for a set of markers across the genome in two separate studies. The family information has also been pooled across the two studies so that the combined evidence can be assessed. While no genomic region gives overwhelming support for a testicular cancer predisposition gene, several regions, notably on chromosomes 3, 5, 12 and 18 show suggestive evidence worthy of further examination. The Consortium is now attempting to identify further families in an attempt to confirm or deny these leads.

Original languageEnglish
Pages (from-to)64-72
Number of pages9
JournalAPMIS
Volume106
Issue number1
Publication statusPublished - 1998

Keywords

  • Family studies
  • Linkage
  • Mapping
  • Susceptibility gene
  • Testis cancer

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