Cannabinoid CB1 and CB2 receptor signaling and bias

Mikkel Søes Ibsen, Mark Connor, Michelle Glass

Research output: Contribution to journalReview articlepeer-review

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An agonist that acts through a single receptor can activate numerous signaling pathways. Recent studies have suggested that different ligands can differentially activate these pathways by stabilizing a limited range of receptor conformations, which in turn preferentially drive different downstream signaling cascades. This concept, termed “biased signaling” represents an exciting therapeutic opportunity to target specific pathways that elicit only desired effects, while avoiding undesired effects mediated by different signaling cascades. The cannabinoid receptors CB1 and CB2 each activate multiple pathways, and evidence is emerging for bias within these pathways. This review will summarize the current evidence for biased signaling through cannabinoid receptor subtypes CB1 and CB2.
Original languageEnglish
Pages (from-to)48-60
Number of pages13
JournalCannabis and Cannabinoid Research
Issue number1
Publication statusPublished - 1 Mar 2017

Bibliographical note

Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • agonist bias
  • cannabinoid receptors
  • functional selectivity
  • G protein-coupled receptor


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