Cannabinoid-induced increase of quantal size and enhanced neuromuscular transmission

Marco Morsch*, Dario A. Protti, Delfine Cheng, Filip Braet, Roger S. Chung, Stephen W. Reddel, William D. Phillips

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)
53 Downloads (Pure)

Abstract

Cannabinoids exert dynamic control over many physiological processes including memory formation, cognition and pain perception. In the central nervous system endocannabinoids mediate negative feedback of quantal transmitter release following postsynaptic depolarization. The influence of cannabinoids in the peripheral nervous system is less clear and might have broad implications for the therapeutic application of cannabinoids. We report a novel cannabinoid effect upon the mouse neuromuscular synapse: Acutely increasing synaptic vesicle volume and raising the quantal amplitudes. In a mouse model of myasthenia gravis the cannabinoid receptor agonist WIN 55,212 reversed fatiguing failure of neuromuscular transmission, suggesting future therapeutic potential. Our data suggest an endogenous pathway by which cannabinoids might help to regulate transmitter release at the neuromuscular junction.

Original languageEnglish
Article number4685
Pages (from-to)1-8
Number of pages8
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 16 Mar 2018

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher

Keywords

  • neuromuscular disease
  • neuromuscular junction
  • synaptic vesicle exocytosis

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