Cardiovascular components of the defence reaction evoked by excitation of neuronal cell bodies in the midbrain periaqueductal grey of the cat

Alan McDougall, Roger Dampney, Richard Bandler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

In the anaesthetized and paralyzed cat the cardiovascular pattern characteristic of the defence reaction, i.e. skeletal muscle vasodilatation, tachycardia and increased arterial pressure, was elicited by microinjections (0.40 μl) of the excitatory amino acid, dl-homocysteic acid (DLH), into the midbrain periaqueductal grey (PAG) matter. In contrast, injections of DLH into the midbrain tegmentum failed to elicit the cardiovascular components of the defence reaction. As injections of DLH depolarize cell bodies but not axons, the results indicate that the midbrain PAG, but not the adjacent tegmentum, contains a population of neurones whose excitation elicits these reactions. Further, the data suggested that such neurones may be localized preferentially within the caudal half of the midbrain PAG.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalNeuroscience Letters
Volume60
Issue number1
DOIs
Publication statusPublished - 16 Sept 1985
Externally publishedYes

Keywords

  • cat
  • defence reaction
  • dl-homocysteic acid
  • excitatory amino acid
  • midbrain periaqueductal grey
  • skeletal muscle vasodilatation

Fingerprint

Dive into the research topics of 'Cardiovascular components of the defence reaction evoked by excitation of neuronal cell bodies in the midbrain periaqueductal grey of the cat'. Together they form a unique fingerprint.

Cite this