Cardiovascular effects of angiotensin II in the rostral ventrolateral medulla: The push-pull hypothesis

Roger A L Dampney; P. S P Tan; M. J. Sheriff; M. A P Fontes; J. Horiuchi

doi:10.1007/s11906-007-0040-4

Cardiovascular effects of angiotensin II in the rostral ventrolateral medulla: The push-pull hypothesis

Roger A L Dampney^*, P. S P Tan, M. J. Sheriff, M. A P Fontes, J. Horiuchi

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

45 Citations (Scopus)

Abstract

Neurons within the rostral ventrolateral medulla (RVLM) play a pivotal role in the tonic and phasic control of blood pressure. This region also contains a high density of angiotensin II type 1 (AT1) receptors. There is evidence that tonic activation of AT1 receptors in the RVLM contributes to an increased sympathetic vasomotor activity in some models of hypertension. At the same time, under certain conditions, activation of AT1 receptors in the RVLM can cause sympathoinhibition. In this review we argue that the effect of endogenous angiotensin II in the RVLM on sympathetic vasomotor activity depends upon the balance between tonic excitatory and inhibitory effects on sympathetic premotor neurons mediated by AT1 receptors within this region, and that this balance may be altered in different physiological or pathophysiological conditions.

Original language	English
Pages (from-to)	222-227
Number of pages	6
Journal	Current Hypertension Reports
Volume	9
Issue number	3
DOIs	https://doi.org/10.1007/s11906-007-0040-4
Publication status	Published - Jun 2007
Externally published	Yes

Access to Document

10.1007/s11906-007-0040-4

Cite this

@article{adb64ef40e3b4a36bc399427d980c6a0,

title = "Cardiovascular effects of angiotensin II in the rostral ventrolateral medulla: The push-pull hypothesis",

abstract = "Neurons within the rostral ventrolateral medulla (RVLM) play a pivotal role in the tonic and phasic control of blood pressure. This region also contains a high density of angiotensin II type 1 (AT1) receptors. There is evidence that tonic activation of AT1 receptors in the RVLM contributes to an increased sympathetic vasomotor activity in some models of hypertension. At the same time, under certain conditions, activation of AT1 receptors in the RVLM can cause sympathoinhibition. In this review we argue that the effect of endogenous angiotensin II in the RVLM on sympathetic vasomotor activity depends upon the balance between tonic excitatory and inhibitory effects on sympathetic premotor neurons mediated by AT1 receptors within this region, and that this balance may be altered in different physiological or pathophysiological conditions.",

author = "Dampney, {Roger A L} and Tan, {P. S P} and Sheriff, {M. J.} and Fontes, {M. A P} and J. Horiuchi",

year = "2007",

month = jun,

doi = "10.1007/s11906-007-0040-4",

language = "English",

volume = "9",

pages = "222--227",

journal = "Current Hypertension Reports",

issn = "1522-6417",

publisher = "Springer, Springer Nature",

number = "3",

}

TY - JOUR

T1 - Cardiovascular effects of angiotensin II in the rostral ventrolateral medulla

T2 - The push-pull hypothesis

AU - Dampney, Roger A L

AU - Tan, P. S P

AU - Sheriff, M. J.

AU - Fontes, M. A P

AU - Horiuchi, J.

PY - 2007/6

Y1 - 2007/6

N2 - Neurons within the rostral ventrolateral medulla (RVLM) play a pivotal role in the tonic and phasic control of blood pressure. This region also contains a high density of angiotensin II type 1 (AT1) receptors. There is evidence that tonic activation of AT1 receptors in the RVLM contributes to an increased sympathetic vasomotor activity in some models of hypertension. At the same time, under certain conditions, activation of AT1 receptors in the RVLM can cause sympathoinhibition. In this review we argue that the effect of endogenous angiotensin II in the RVLM on sympathetic vasomotor activity depends upon the balance between tonic excitatory and inhibitory effects on sympathetic premotor neurons mediated by AT1 receptors within this region, and that this balance may be altered in different physiological or pathophysiological conditions.

AB - Neurons within the rostral ventrolateral medulla (RVLM) play a pivotal role in the tonic and phasic control of blood pressure. This region also contains a high density of angiotensin II type 1 (AT1) receptors. There is evidence that tonic activation of AT1 receptors in the RVLM contributes to an increased sympathetic vasomotor activity in some models of hypertension. At the same time, under certain conditions, activation of AT1 receptors in the RVLM can cause sympathoinhibition. In this review we argue that the effect of endogenous angiotensin II in the RVLM on sympathetic vasomotor activity depends upon the balance between tonic excitatory and inhibitory effects on sympathetic premotor neurons mediated by AT1 receptors within this region, and that this balance may be altered in different physiological or pathophysiological conditions.

UR - http://www.scopus.com/inward/record.url?scp=34250164280&partnerID=8YFLogxK

U2 - 10.1007/s11906-007-0040-4

DO - 10.1007/s11906-007-0040-4

M3 - Review article

C2 - 17519129

AN - SCOPUS:34250164280

SN - 1522-6417

VL - 9

SP - 222

EP - 227

JO - Current Hypertension Reports

JF - Current Hypertension Reports

IS - 3

ER -

Cardiovascular effects of angiotensin II in the rostral ventrolateral medulla: The push-pull hypothesis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this