CARDIOVASCULAR EFFECTS OF STIMULATION OF NEURONES WITHIN THE ‘DEFENCE AREA’ OF THE HYPOTHALAMUS AND MIDBRAIN OF THE RABBIT

Esther Tan; R. A L Dampney

doi:10.1111/j.1440-1681.1983.tb00201.x

CARDIOVASCULAR EFFECTS OF STIMULATION OF NEURONES WITHIN THE ‘DEFENCE AREA’ OF THE HYPOTHALAMUS AND MIDBRAIN OF THE RABBIT

Esther Tan^*, R. A L Dampney

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

1. In anaesthetized rabbits, electrical stimulation applied at many sites within the medial hypothalamus and dorsal midbrain elicited a skeletal muscle vasodilatation. 2. Vasodilator responses were only elicited by microinjections of glutamate ions (which excite only cell bodies) into a much more restricted region: the periaqueductal grey (PAG) in the midbrain, and the ventromedial nucleus in the hypothalamus. 3. The results suggest that cell groups within the PAG and ventromedial nucleus are capable of generating skeletal muscle vasodilatation, which is characteristic of the ‘defence reaction’. At other sites within the ‘defence area’, the cardiovascular response to electrical stimulation arises from axons of passage.

Original language	English
Pages (from-to)	299-303
Number of pages	5
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1111/j.1440-1681.1983.tb00201.x
Publication status	Published - 1983
Externally published	Yes

Keywords

baroreceptors
central vasomotor pathways
vasodilatation

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10.1111/j.1440-1681.1983.tb00201.x

Cite this

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title = "CARDIOVASCULAR EFFECTS OF STIMULATION OF NEURONES WITHIN THE {\textquoteleft}DEFENCE AREA{\textquoteright} OF THE HYPOTHALAMUS AND MIDBRAIN OF THE RABBIT",

abstract = "1. In anaesthetized rabbits, electrical stimulation applied at many sites within the medial hypothalamus and dorsal midbrain elicited a skeletal muscle vasodilatation. 2. Vasodilator responses were only elicited by microinjections of glutamate ions (which excite only cell bodies) into a much more restricted region: the periaqueductal grey (PAG) in the midbrain, and the ventromedial nucleus in the hypothalamus. 3. The results suggest that cell groups within the PAG and ventromedial nucleus are capable of generating skeletal muscle vasodilatation, which is characteristic of the {\textquoteleft}defence reaction{\textquoteright}. At other sites within the {\textquoteleft}defence area{\textquoteright}, the cardiovascular response to electrical stimulation arises from axons of passage.",

keywords = "baroreceptors, central vasomotor pathways, vasodilatation",

author = "Esther Tan and Dampney, {R. A L}",

year = "1983",

doi = "10.1111/j.1440-1681.1983.tb00201.x",

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AU - Dampney, R. A L

PY - 1983

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N2 - 1. In anaesthetized rabbits, electrical stimulation applied at many sites within the medial hypothalamus and dorsal midbrain elicited a skeletal muscle vasodilatation. 2. Vasodilator responses were only elicited by microinjections of glutamate ions (which excite only cell bodies) into a much more restricted region: the periaqueductal grey (PAG) in the midbrain, and the ventromedial nucleus in the hypothalamus. 3. The results suggest that cell groups within the PAG and ventromedial nucleus are capable of generating skeletal muscle vasodilatation, which is characteristic of the ‘defence reaction’. At other sites within the ‘defence area’, the cardiovascular response to electrical stimulation arises from axons of passage.

AB - 1. In anaesthetized rabbits, electrical stimulation applied at many sites within the medial hypothalamus and dorsal midbrain elicited a skeletal muscle vasodilatation. 2. Vasodilator responses were only elicited by microinjections of glutamate ions (which excite only cell bodies) into a much more restricted region: the periaqueductal grey (PAG) in the midbrain, and the ventromedial nucleus in the hypothalamus. 3. The results suggest that cell groups within the PAG and ventromedial nucleus are capable of generating skeletal muscle vasodilatation, which is characteristic of the ‘defence reaction’. At other sites within the ‘defence area’, the cardiovascular response to electrical stimulation arises from axons of passage.

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KW - central vasomotor pathways

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JO - Clinical and Experimental Pharmacology and Physiology

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ER -

CARDIOVASCULAR EFFECTS OF STIMULATION OF NEURONES WITHIN THE ‘DEFENCE AREA’ OF THE HYPOTHALAMUS AND MIDBRAIN OF THE RABBIT

Abstract

Keywords

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