Carriage of serogroup W-135, ET-37 meningococci in The Gambia: implications for immunisation policy?

Jenny M. MacLennan; Rachel Urwin; Steven Obaro; David  Griffiths; Brian Greenwood; Martin C. J. Greenwood

doi:10.1016/s0140-6736(00)02734-3

Carriage of serogroup W-135, ET-37 meningococci in The Gambia: implications for immunisation policy?

Jenny M. MacLennan, Rachel Urwin, Steven Obaro, David Griffiths, Brian Greenwood, Martin C. J. Greenwood

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Abstract

We found high levels of symptomless carriage of a hyperinvasive Neisseria meningitidis strain (electrophoretic type 37 [ET-37], serogroup W-135) during a vaccine trial in Gambian children in 1996. Serogroup C, ET-37 complex meningococci cause 30–40% of meningococcal disease in countries such as the UK, and have a point prevalence of 0·5–1·0%. The recent Haj-associated spread of serogroup W-135, ET-37 complex meningococci, which has been accompanied by numerous secondary cases, might be explained by the apparently raised carriage rates reported here.

Original language	English
Pages (from-to)	1078
Number of pages	1
Journal	The Lancet
Volume	356
Issue number	9235
DOIs	https://doi.org/10.1016/s0140-6736(00)02734-3
Publication status	Published - Sept 2000
Externally published	Yes

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title = "Carriage of serogroup W-135, ET-37 meningococci in The Gambia: implications for immunisation policy?",

abstract = "We found high levels of symptomless carriage of a hyperinvasive Neisseria meningitidis strain (electrophoretic type 37 [ET-37], serogroup W-135) during a vaccine trial in Gambian children in 1996. Serogroup C, ET-37 complex meningococci cause 30–40\% of meningococcal disease in countries such as the UK, and have a point prevalence of 0·5–1·0\%. The recent Haj-associated spread of serogroup W-135, ET-37 complex meningococci, which has been accompanied by numerous secondary cases, might be explained by the apparently raised carriage rates reported here.",

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T1 - Carriage of serogroup W-135, ET-37 meningococci in The Gambia

T2 - implications for immunisation policy?

AU - MacLennan, Jenny M.

AU - Urwin, Rachel

AU - Obaro, Steven

AU - Griffiths, David

AU - Greenwood, Brian

AU - Greenwood, Martin C. J.

PY - 2000/9

Y1 - 2000/9

N2 - We found high levels of symptomless carriage of a hyperinvasive Neisseria meningitidis strain (electrophoretic type 37 [ET-37], serogroup W-135) during a vaccine trial in Gambian children in 1996. Serogroup C, ET-37 complex meningococci cause 30–40% of meningococcal disease in countries such as the UK, and have a point prevalence of 0·5–1·0%. The recent Haj-associated spread of serogroup W-135, ET-37 complex meningococci, which has been accompanied by numerous secondary cases, might be explained by the apparently raised carriage rates reported here.

AB - We found high levels of symptomless carriage of a hyperinvasive Neisseria meningitidis strain (electrophoretic type 37 [ET-37], serogroup W-135) during a vaccine trial in Gambian children in 1996. Serogroup C, ET-37 complex meningococci cause 30–40% of meningococcal disease in countries such as the UK, and have a point prevalence of 0·5–1·0%. The recent Haj-associated spread of serogroup W-135, ET-37 complex meningococci, which has been accompanied by numerous secondary cases, might be explained by the apparently raised carriage rates reported here.

UR - https://www.scopus.com/pages/publications/0034706229

U2 - 10.1016/s0140-6736(00)02734-3

DO - 10.1016/s0140-6736(00)02734-3

M3 - Article

SN - 0140-6736

VL - 356

SP - 1078

JO - The Lancet

JF - The Lancet

IS - 9235

ER -

Carriage of serogroup W-135, ET-37 meningococci in The Gambia: implications for immunisation policy?

Abstract

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