Carrier detection in X-linked diseases

G. A. Nicholson

    Research output: Contribution to journalReview articlepeer-review


    Some forty years ago J. B. S. Haldane proposed some estimates concerning the incidence and new occurrence of mutations producing X-linked lethal disorders. As is described in this article, recent results indicate that Haldane's estimates may have been incorrect, that there may be a possible heterozygote advantage in some X-linked diseases, and that certain X-linked diseases may be controllable through improved carrier detection programmes.

    Original languageEnglish
    Pages (from-to)169-170
    Number of pages2
    JournalTrends in Neurosciences
    Issue numberC
    Publication statusPublished - 1979


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