Catalytic and antibacterial properties of 3-dentate carboxamide Pd/Pt complexes obtained via a benign route

Mahsa Kiani, Mojtaba Bagherzadeh*, Soraya Meghdadi, Farzaneh Fadaei-Tirani, Kurt Schenk-Joß, Navid Rabiee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The complexes PdII(qcq)(OAc) and PtII(qcq)Cl have been synthesized using environmentally benign synthesized ligands and characterized by elemental analyses: Fourier transform infrared spectroscopy, UV–visible spectroscopy, 1H NMR spectroscopy, and X-ray diffraction. The catalytic activity of the complex was assessed, in different media, for the Mizoroki–Heck coupling reaction for typical aryl halides and terminal olefins under aerobic conditions. Since the base and the solvent were found to influence the efficiency of the reaction, reaction conditions, temperature, time, and the amount of K3PO4 and a mixture of H2O/PEG, were optimized. We found, for the Mizoroki–Heck reaction coupling less reactive aryl chloride derivatives with olefins, promising activity for palladium catalysts. The electrochemical behavior of Hqcq and the Pd(II) complex was investigated by cyclic voltammetry and irreversible PdII/I reductions were observed. Hqcq and the Pd(II) and Pt(II) complexes were also screened for their in vitro antibacterial activity. They showed promising antibacterial activity comparable to that of the antibiotic penicillin.

Original languageEnglish
Article numbere5531
Pages (from-to)1-18
Number of pages18
JournalApplied Organometallic Chemistry
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 2020
Externally publishedYes

Keywords

  • carboxamide complexes
  • cyclic voltammetry and antibacterial activity
  • Pd(II) complexes
  • X-ray crystal structure
  • Mizoroki–Heck coupling reaction

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