Catecholaminergic C3 neurons are sympathoexcitatory and involved in glucose homeostasis

Clément Menuet, Charles P. Sevigny, Angela A. Connelly, Jaspreet K. Bassi, Nikola Jancovski, David A. Williams, Colin R. Anderson, Ida J. Llewellyn-Smith, Angelina Y. Fong, Andrew M. Allen*

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Brainstem catecholaminergic neurons play key roles in the autonomic, neuroendocrine, and behavioral responses to glucoprivation, yet the functions of the individual groups are not fully understood. Adrenergic C3 neurons project widely throughout the brain, including densely to sympathetic preganglionic neurons in the spinal cord, yet their function is completely unknown. Here we demonstrate in rats that optogenetic stimulation of C3 neurons induces sympathoexcitatory, cardiovasomotor functions. These neurons are activated by glucoprivation, but unlike the C1 cell group, not by hypotension. The cardiovascular activation induced by C3 neurons is less than that induced by optogenetic stimulation of C1 neurons; however, combined stimulation produces additive sympathoexcitatory and cardiovascular effects. The varicose axons of C3 neurons largely overlap with those of C1 neurons in the region of sympathetic preganglionic neurons in the spinal cord; however, regional differences point to effects on different sympathetic outflows. These studies definitively demonstrate the first known function of C3 neurons as unique cardiovasomotor stimulatory cells, embedded in the brainstem networks regulating cardiorespiratory activity and the response to glucoprivation.

Original languageEnglish
Pages (from-to)15110-15122
Number of pages13
JournalJournal of Neuroscience
Volume34
Issue number45
DOIs
Publication statusPublished - 5 Nov 2014
Externally publishedYes

Keywords

  • Channelrhodopsin
  • Glucoprivation
  • Rostral ventrolateral medulla
  • Sympathetic nervous system

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    Menuet, C., Sevigny, C. P., Connelly, A. A., Bassi, J. K., Jancovski, N., Williams, D. A., ... Allen, A. M. (2014). Catecholaminergic C3 neurons are sympathoexcitatory and involved in glucose homeostasis. Journal of Neuroscience, 34(45), 15110-15122. https://doi.org/10.1523/JNEUROSCI.3179-14.2014