Caudate nucleus volumes and genetic determinants of homocysteine metabolism in the prediction of psychomotor speed in older persons with depression

Sharon Naismith*, Ian Hickie, Philip B. Ward, Keelin Turner, Elizabeth Scott, Craig Little, Philip Mitchell, Kay Wilhelm, Gordon Parker

*Corresponding author for this work

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Objective: The authors sought to determine whether caudate nucleus volumes or specific genotypes predict psychomotor slowing in older persons with depression. Method: Forty-seven persons with depression (mean age=51.8 years, SD=12.4) and 20 healthy volunteers (mean age=56.1 years, SD=9.8) underwent clinical assessments, a neuropsychological test of psychomotor speed (part A of the Trail Making Test), high-resolution magnetic resonance imaging scans, and genotyping for the apolipoprotein E ε4 allele and a mutation of the methylenetetrahydrofolate reductase enzyme. Results: Multivariate analyses revealed that psychomotor speed was uniquely predicted by age, a diagnosis of depression, right caudate nucleus volume, and mutation of the methylenetetrahydrofolate reductase enzyme. Conclusions: Psychomotor slowing, a key clinical and cognitive phenomenon in older persons with depression, is predicted by reduced caudate nucleus volumes and genetic determinants of homocysteine metabolism.

Original languageEnglish
Pages (from-to)2096-2098
Number of pages3
JournalAmerican Journal of Psychiatry
Volume159
Issue number12
DOIs
Publication statusPublished - 1 Dec 2002
Externally publishedYes

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