Causative pathogens of endophthalmitis after intravitreal anti-VEGF injection: an international multicenter study

Catharina Busch, Matias Iglicki, Mali Okada, Pierre Henry Gabrielle, Shai Cohen, Miriana Mariussi, Atchara Amphornphruet, Zafer Cebeci, Voraporn Chaikitmongkol, Aude Couturier, Samantha Fraser-Bell, Adrian T. Fung, Danilo Iannetta, Liga Radecka, Inês Laíns, Tiago M. Rodrigues, Marco Lupidi, Małgorzata Ozimek, Anna Sala-Puigdollers, Matus RehakAnat Loewenstein, Dinah Zur*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)


    Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure. Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers. Results: Eighty-three cases with 87 identified pathogens were included. Coagulase-negative staphylococci (59%) and viridans streptococci (15%) were the most frequent pathogens found. The use of postoperative antibiotics and performance of injections in an operating room setting significantly reduced the rate of streptococcus-induced endophthalmitis cases (p = 0.01 for both). Conclusion: We found a statistically significant lower rate of postinjectional local antibiotic therapy and operating room-based procedures among the streptococcus-induced cases compared to cases caused by other organisms.

    Original languageEnglish
    Pages (from-to)211-219
    Number of pages9
    Issue number4
    Publication statusPublished - 1 Apr 2019


    • Endophthalmitis
    • Intravitreal injection
    • Vascular endothelial growth factor


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