Cdx and Hox Genes Differentially Regulate Posterior Axial Growth in Mammalian Embryos

Teddy Young, Jennifer Elizabeth Rowland, Cesca van de Ven, Monika Bialecka, Ana Novoa, Marta Carapuco, Johan van Nes, Wim de Graaff, Isabelle Duluc, Jean Noël Freund, Felix Beck, Moises Mallo, Jacqueline Deschamps*

*Corresponding author for this work

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Hox and Cdx transcription factors regulate embryonic positional identities. Cdx mutant mice display posterior body truncations of the axial skeleton, neuraxis, and caudal urorectal structures. We show that trunk Hox genes stimulate axial extension, as they can largely rescue these Cdx mutant phenotypes. Conversely, posterior (paralog group 13) Hox genes can prematurely arrest posterior axial growth when precociously expressed. Our data suggest that the transition from trunk to tail Hox gene expression successively regulates the construction and termination of axial structures in the mouse embryo. Thus, Hox genes seem to differentially orchestrate posterior expansion of embryonic tissues during axial morphogenesis as an integral part of their function in specifying head-to-tail identity. In addition, we present evidence that Cdx and Hox transcription factors exert these effects by controlling Wnt signaling. Concomitant regulation of Cyp26a1 expression, restraining retinoic acid signaling away from the posterior growth zone, may likewise play a role in timing the trunk-tail transition.

Original languageEnglish
Pages (from-to)516-526
Number of pages11
JournalDevelopmental Cell
Volume17
Issue number4
DOIs
Publication statusPublished - 20 Oct 2009
Externally publishedYes

Keywords

  • DEVBIO

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