生物细胞仿生药物递送系统在癌症治疗中的应用

Translated title of the contribution: Cell-derived biomimetic drug delivery systems for cancer therapy

Wenya He, Yan Zou, Meng Zheng, Bingyang Shi

Research output: Contribution to journalArticle

Abstract

Nano-drugs hold great potential in the area of precision medicine. However, the easy recognition and fast clearance of nanoparticles by the immune systems has greatly hindered their application in cancer therapy. Inspired by the natural systems, cell-derived biomimetic drug delivery systems have aroused significant attention in recent years. This strategy, in which nano-drug carriers were surface-coated with endogenous cell membranes or co-incubated with live cells to form drug-carrying cells, organically combines the unique functionalities of cells and synthetic nanomaterials for effective delivery of therapeutic agents. On one hand, it can decrease the immunogenicity of nanodrugs, and prolong their in vivo blood circulation time. On the other hand, it will endow the nano-drugs with enhanced tumor targeting ability. In this review, we introduce the research progress of the application of cell-derived biomimetic drug delivery systems in cancer therapy, and discuss the challenges for additional breakthroughs in this field.
Original languageChinese
Pages (from-to)1203-1212
Number of pages10
JournalSCIENTIA SINICA Chimica
Volume49
Issue number9
DOIs
Publication statusPublished - 2019
Externally publishedYes

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Bibliographical note

Transliterate article title: "shēng wù xì bāo fǎng shēng yào wù dì sòng xì tǒng zài ái zhèng zhì liáo zhōng de yīng yòng"

Keywords

  • biomimetic functionalization
  • nano-drug
  • cell
  • cancer therapy

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