Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy

Jiefei Wang; Zhongjie Wang; Yong Zhong; Yan Zou; Chong Wang; Haigang Wu; Albert Lee; Weitao Yang; Xiao Wang; Yanjie Liu; Dongya Zhang; Jiliang Yan; Mingcong Hao; Meng Zheng; Roger Chung; Feng Bai; Bingyang Shi

doi:10.1016/j.biomaterials.2019.119576

Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy

Jiefei Wang, Zhongjie Wang, Yong Zhong, Yan Zou, Chong Wang, Haigang Wu, Albert Lee, Weitao Yang, Xiao Wang, Yanjie Liu, Dongya Zhang, Jiliang Yan, Mingcong Hao, Meng Zheng, Roger Chung, Feng Bai, Bingyang Shi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Dual-modal imaging guided photodynamic therapy (PDT) of multifunctional nanocomposites holds great promise for precision tumor theranostics. However, poor heterogeneous interfacial compatibility between functional components, low hydrophilicity and complicated preparation of nanocomposites remain major obstacles for further bioapplication. Herein, a facile central metal-derived co-assembly strategy is developed to effectively integrate gadolinium porphyrin (GdTPP) contrast agent and Zinc porphyrin (ZnTPP) photosensitizer into a homogeneous GdTPP/ZnTPP nanocomposites (GZNs). GZNs possesses the following advantages: (1) Greatly improved interfacial compatibility facilitated by incorporating two metalporphyrins with same group (phenyl-) and different central metal atoms (Zn and Gd) leading to higher yield (4.7–5 fold) than either monocomponent nanoparticles. (2) Poor dispersity of GdTPP nanoparticles is greatly improved after integrating with ZnTPP blocks. (3) The GZNs inherit excellent fluorescence imaging, high relaxation rate (8.18 mM−1 s−1) and singlet oxygen production from two raw metalporphyrins. After camouflaging with homotypic cancer cell membrane for immunologic escape, the HeLa membrane coated GZNs (mGZNs) show enhanced in vivo MR/FL imaging guided anti-tumor targeting efficiency of 80.6% for HeLa cells. Our new strategy using central metal-derived co-assembly of homogeneous building blocks greatly improves interfacial compatibility to achieve combined functions for visualized cancer theranostics.

Original language	English
Article number	119576
Pages (from-to)	1-13
Number of pages	13
Journal	Biomaterials
Volume	229
DOIs	https://doi.org/10.1016/j.biomaterials.2019.119576
Publication status	Published - Jan 2020

Bibliographical note

A corrigendum exists for this article and can be found in Biomaterials (2020) Vol 235 at doi: 10.1016/j.biomaterials.2020.119758

Keywords

Co-assembly
Dual-modal imaging
Nanocomposites
PDT
Porphyrin

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10.1016/j.biomaterials.2019.119576

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Wang, J., Wang, Z., Zhong, Y., Zou, Y., Wang, C., Wu, H., Lee, A., Yang, W., Wang, X., Liu, Y., Zhang, D., Yan, J., Hao, M., Zheng, M., Chung, R., Bai, F., & Shi, B. (2020). Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy. Biomaterials, 229, 1-13. Article 119576. https://doi.org/10.1016/j.biomaterials.2019.119576

@article{34c377f9851e480583631d3c36878231,

title = "Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy",

abstract = "Dual-modal imaging guided photodynamic therapy (PDT) of multifunctional nanocomposites holds great promise for precision tumor theranostics. However, poor heterogeneous interfacial compatibility between functional components, low hydrophilicity and complicated preparation of nanocomposites remain major obstacles for further bioapplication. Herein, a facile central metal-derived co-assembly strategy is developed to effectively integrate gadolinium porphyrin (GdTPP) contrast agent and Zinc porphyrin (ZnTPP) photosensitizer into a homogeneous GdTPP/ZnTPP nanocomposites (GZNs). GZNs possesses the following advantages: (1) Greatly improved interfacial compatibility facilitated by incorporating two metalporphyrins with same group (phenyl-) and different central metal atoms (Zn and Gd) leading to higher yield (4.7–5 fold) than either monocomponent nanoparticles. (2) Poor dispersity of GdTPP nanoparticles is greatly improved after integrating with ZnTPP blocks. (3) The GZNs inherit excellent fluorescence imaging, high relaxation rate (8.18 mM−1 s−1) and singlet oxygen production from two raw metalporphyrins. After camouflaging with homotypic cancer cell membrane for immunologic escape, the HeLa membrane coated GZNs (mGZNs) show enhanced in vivo MR/FL imaging guided anti-tumor targeting efficiency of 80.6% for HeLa cells. Our new strategy using central metal-derived co-assembly of homogeneous building blocks greatly improves interfacial compatibility to achieve combined functions for visualized cancer theranostics.",

keywords = "Co-assembly, Dual-modal imaging, Nanocomposites, PDT, Porphyrin",

author = "Jiefei Wang and Zhongjie Wang and Yong Zhong and Yan Zou and Chong Wang and Haigang Wu and Albert Lee and Weitao Yang and Xiao Wang and Yanjie Liu and Dongya Zhang and Jiliang Yan and Mingcong Hao and Meng Zheng and Roger Chung and Feng Bai and Bingyang Shi",

note = "A corrigendum exists for this article and can be found in Biomaterials (2020) Vol 235 at doi: 10.1016/j.biomaterials.2020.119758",

year = "2020",

month = jan,

doi = "10.1016/j.biomaterials.2019.119576",

language = "English",

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issn = "0142-9612",

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Wang, J, Wang, Z, Zhong, Y, Zou, Y, Wang, C, Wu, H, Lee, A, Yang, W, Wang, X, Liu, Y, Zhang, D, Yan, J, Hao, M, Zheng, M, Chung, R, Bai, F & Shi, B 2020, 'Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy', Biomaterials, vol. 229, 119576, pp. 1-13. https://doi.org/10.1016/j.biomaterials.2019.119576

TY - JOUR

T1 - Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy

AU - Wang, Jiefei

AU - Wang, Zhongjie

AU - Zhong, Yong

AU - Zou, Yan

AU - Wang, Chong

AU - Wu, Haigang

AU - Lee, Albert

AU - Yang, Weitao

AU - Wang, Xiao

AU - Liu, Yanjie

AU - Zhang, Dongya

AU - Yan, Jiliang

AU - Hao, Mingcong

AU - Zheng, Meng

AU - Chung, Roger

AU - Bai, Feng

AU - Shi, Bingyang

N1 - A corrigendum exists for this article and can be found in Biomaterials (2020) Vol 235 at doi: 10.1016/j.biomaterials.2020.119758

PY - 2020/1

Y1 - 2020/1

N2 - Dual-modal imaging guided photodynamic therapy (PDT) of multifunctional nanocomposites holds great promise for precision tumor theranostics. However, poor heterogeneous interfacial compatibility between functional components, low hydrophilicity and complicated preparation of nanocomposites remain major obstacles for further bioapplication. Herein, a facile central metal-derived co-assembly strategy is developed to effectively integrate gadolinium porphyrin (GdTPP) contrast agent and Zinc porphyrin (ZnTPP) photosensitizer into a homogeneous GdTPP/ZnTPP nanocomposites (GZNs). GZNs possesses the following advantages: (1) Greatly improved interfacial compatibility facilitated by incorporating two metalporphyrins with same group (phenyl-) and different central metal atoms (Zn and Gd) leading to higher yield (4.7–5 fold) than either monocomponent nanoparticles. (2) Poor dispersity of GdTPP nanoparticles is greatly improved after integrating with ZnTPP blocks. (3) The GZNs inherit excellent fluorescence imaging, high relaxation rate (8.18 mM−1 s−1) and singlet oxygen production from two raw metalporphyrins. After camouflaging with homotypic cancer cell membrane for immunologic escape, the HeLa membrane coated GZNs (mGZNs) show enhanced in vivo MR/FL imaging guided anti-tumor targeting efficiency of 80.6% for HeLa cells. Our new strategy using central metal-derived co-assembly of homogeneous building blocks greatly improves interfacial compatibility to achieve combined functions for visualized cancer theranostics.

AB - Dual-modal imaging guided photodynamic therapy (PDT) of multifunctional nanocomposites holds great promise for precision tumor theranostics. However, poor heterogeneous interfacial compatibility between functional components, low hydrophilicity and complicated preparation of nanocomposites remain major obstacles for further bioapplication. Herein, a facile central metal-derived co-assembly strategy is developed to effectively integrate gadolinium porphyrin (GdTPP) contrast agent and Zinc porphyrin (ZnTPP) photosensitizer into a homogeneous GdTPP/ZnTPP nanocomposites (GZNs). GZNs possesses the following advantages: (1) Greatly improved interfacial compatibility facilitated by incorporating two metalporphyrins with same group (phenyl-) and different central metal atoms (Zn and Gd) leading to higher yield (4.7–5 fold) than either monocomponent nanoparticles. (2) Poor dispersity of GdTPP nanoparticles is greatly improved after integrating with ZnTPP blocks. (3) The GZNs inherit excellent fluorescence imaging, high relaxation rate (8.18 mM−1 s−1) and singlet oxygen production from two raw metalporphyrins. After camouflaging with homotypic cancer cell membrane for immunologic escape, the HeLa membrane coated GZNs (mGZNs) show enhanced in vivo MR/FL imaging guided anti-tumor targeting efficiency of 80.6% for HeLa cells. Our new strategy using central metal-derived co-assembly of homogeneous building blocks greatly improves interfacial compatibility to achieve combined functions for visualized cancer theranostics.

KW - Co-assembly

KW - Dual-modal imaging

KW - Nanocomposites

KW - PDT

KW - Porphyrin

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UR - https://doi.org/10.1016/j.biomaterials.2020.119758

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DO - 10.1016/j.biomaterials.2019.119576

M3 - Article

C2 - 31968289

SN - 0142-9612

VL - 229

SP - 1

EP - 13

JO - Biomaterials

JF - Biomaterials

M1 - 119576

ER -

Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy

Abstract

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Keywords

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