Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy

Jiefei Wang, Zhongjie Wang, Yong Zhong, Yan Zou, Chong Wang, Haigang Wu, Albert Lee, Weitao Yang, Xiao Wang, Yanjie Liu, Dongya Zhang, Jiliang Yan, Mingcong Hao, Meng Zheng, Roger Chung, Feng Bai, Bingyang Shi*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)


Dual-modal imaging guided photodynamic therapy (PDT) of multifunctional nanocomposites holds great promise for precision tumor theranostics. However, poor heterogeneous interfacial compatibility between functional components, low hydrophilicity and complicated preparation of nanocomposites remain major obstacles for further bioapplication. Herein, a facile central metal-derived co-assembly strategy is developed to effectively integrate gadolinium porphyrin (GdTPP) contrast agent and Zinc porphyrin (ZnTPP) photosensitizer into a homogeneous GdTPP/ZnTPP nanocomposites (GZNs). GZNs possesses the following advantages: (1) Greatly improved interfacial compatibility facilitated by incorporating two metalporphyrins with same group (phenyl-) and different central metal atoms (Zn and Gd) leading to higher yield (4.7–5 fold) than either monocomponent nanoparticles. (2) Poor dispersity of GdTPP nanoparticles is greatly improved after integrating with ZnTPP blocks. (3) The GZNs inherit excellent fluorescence imaging, high relaxation rate (8.18 mM−1 s−1) and singlet oxygen production from two raw metalporphyrins. After camouflaging with homotypic cancer cell membrane for immunologic escape, the HeLa membrane coated GZNs (mGZNs) show enhanced in vivo MR/FL imaging guided anti-tumor targeting efficiency of 80.6% for HeLa cells. Our new strategy using central metal-derived co-assembly of homogeneous building blocks greatly improves interfacial compatibility to achieve combined functions for visualized cancer theranostics.
Original languageEnglish
Article number119576
Pages (from-to)1-13
Number of pages13
Publication statusPublished - Jan 2020


Bibliographical note

A corrigendum exists for this article and can be found in Biomaterials (2020) Vol 235 at doi: 10.1016/j.biomaterials.2020.119758


  • Co-assembly
  • Dual-modal imaging
  • Nanocomposites
  • PDT
  • Porphyrin

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