TY - JOUR
T1 - CENTRAL NEURONS AND NEUROTRANSMITTERS IN THE CONTROL OF BLOOD PRESSURE
AU - Chalmers, John
AU - Arnolda, Leonard
AU - Llewellyn‐Smith, Ida
AU - Minson, Jane
AU - Pilowsky, Paul
AU - Suzuki, Satoshi
PY - 1994
Y1 - 1994
N2 - 1. In this paper we review recent work from our laboratory on two major pathways important in the central control of blood pressure. 2. We report experiments on the sympatho‐excitatory bulbospinal pathway from the rostral ventral medulla. Here we focus particularly on the role of excitatory amino acids. 3. We review studies on the short inhibitory or depressor pathway ascending from the caudal to the rostral ventral medulla, which is thought to use γ‐aminobutyric acid (GABA) as its neurotransmitter. We report on experiments with the immediate early gene, c‐fos, demonstrating that its expression in the bulbospinal pressor neurons is increased by stimuli that activate these nerves, and that this expression can be blocked in vivo by treatment with an antisense oligonucleotide. We also show that basal and stimulated expression of the c‐fos gene is important in the central control of blood pressure.
AB - 1. In this paper we review recent work from our laboratory on two major pathways important in the central control of blood pressure. 2. We report experiments on the sympatho‐excitatory bulbospinal pathway from the rostral ventral medulla. Here we focus particularly on the role of excitatory amino acids. 3. We review studies on the short inhibitory or depressor pathway ascending from the caudal to the rostral ventral medulla, which is thought to use γ‐aminobutyric acid (GABA) as its neurotransmitter. We report on experiments with the immediate early gene, c‐fos, demonstrating that its expression in the bulbospinal pressor neurons is increased by stimuli that activate these nerves, and that this expression can be blocked in vivo by treatment with an antisense oligonucleotide. We also show that basal and stimulated expression of the c‐fos gene is important in the central control of blood pressure.
KW - antisense oligonucleotide probes
KW - arterial baroreceptor reflexes
KW - caudal ventrolateral medulla
KW - c‐fos
KW - GABA
KW - glutamate
KW - immediate early genes
KW - neuropeptides
KW - rostral ventral medulla
KW - sympathetic nervous system.
UR - http://www.scopus.com/inward/record.url?scp=0028130343&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1681.1994.tb02451.x
DO - 10.1111/j.1440-1681.1994.tb02451.x
M3 - Article
C2 - 7867233
AN - SCOPUS:0028130343
SN - 0305-1870
VL - 21
SP - 819
EP - 829
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
IS - 10
ER -