Abstract
An experiment was designed to investigate the effects of arteriovenous (AV) fistula occlusion on cerebral autoregulation. A right carotid-jugular fistula was created in 63 rats in such a way as to produce an intracranial AV fistula with a loop extension into the neck. The fistula was occluded after an 8-week interval with the rats under both normotension and metaraminol-induced hypertension, and evidence of blood-brain barrier disruption was investigated with an Evans blue dye technique. The results indicate that an intracranial AV fistula may cause cerebral steal which is responsible for a reduction in the threshold for hypertensive breakthrough following fistula occlusion.
| Original language | English |
|---|---|
| Pages (from-to) | 563-567 |
| Number of pages | 5 |
| Journal | Journal of Neurosurgery |
| Volume | 66 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1987 |
| Externally published | Yes |
Keywords
- carotid-jugular fistula
- arteriovenous malformation
- cerebral steal
- blood-brain barrier
- rat