Cerebral arteriovenous malformations, steal, and the hypertensive breakthrough threshold

an experimental study in rats

Michael K. Morgan, Ian Johnston, Michael Besser, David Baines

Research output: Contribution to journalArticle

38 Citations (Scopus)


An experiment was designed to investigate the effects of arteriovenous (AV) fistula occlusion on cerebral autoregulation. A right carotid-jugular fistula was created in 63 rats in such a way as to produce an intracranial AV fistula with a loop extension into the neck. The fistula was occluded after an 8-week interval with the rats under both normotension and metaraminol-induced hypertension, and evidence of blood-brain barrier disruption was investigated with an Evans blue dye technique. The results indicate that an intracranial AV fistula may cause cerebral steal which is responsible for a reduction in the threshold for hypertensive breakthrough following fistula occlusion.

Original languageEnglish
Pages (from-to)563-567
Number of pages5
JournalJournal of Neurosurgery
Issue number4
Publication statusPublished - 1987
Externally publishedYes


  • carotid-jugular fistula
  • arteriovenous malformation
  • cerebral steal
  • blood-brain barrier
  • rat

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