Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease

A putative marker of an ongoing inflammatory process

Amanda McRae, Ralph N. Martins, Justine Fonte, Rudolf Kraftsik, Lorenz Hirt, Judith Miklossy*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Immunocompetent microglia play an important role in the pathogenesis of Alzheimer's disease (AD). Antimicroglial antibodies in the cerebrospinal fluid (CSF) in clinically diagnosed AD patients have been previously recorded. Here, we report the results of the analysis of the CSF from 38 autopsy cases: 7 with definite AD; 14 with mild and 10 with moderate Alzheimer's type pathology; and 7 controls. Antimicroglial antibodies were identified in 70% of patients with definite AD, in 80% of patients with moderate and in 28% of patients with mild Alzheimer's type pathology. CSF antimicroglial antibodies were not observed in any of the control cases. The results show that CSF antimicroglial antibodies are present in the majority of patients with definite AD and also in cases with moderate Alzheimer's type changes. They may also indicate dysregulation of microglial function. Together with previous observations, these findings indicate that compromised immune defense mechanisms play an important role in the pathogenesis of AD.

Original languageEnglish
Pages (from-to)355-363
Number of pages9
JournalExperimental Gerontology
Volume42
Issue number4
DOIs
Publication statusPublished - Apr 2007
Externally publishedYes

Keywords

  • β-Amyloid
  • Alzheimer's disease
  • Antimicroglial antibodies
  • Cerebrospinal fluid
  • Chronic inflammation
  • CSF
  • Microglia

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