Cerebrospinal fluid in long-lasting delirium compared with Alzheimer's dementia

Gideon A. Caplan; Tasha Kvelde; Christina Lai; Swee L. Yap; Cheryl Lin; Mark A. Hill

doi:10.1093/gerona/glq090

Cerebrospinal fluid in long-lasting delirium compared with Alzheimer's dementia

Gideon A. Caplan, Tasha Kvelde, Christina Lai, Swee L. Yap, Cheryl Lin, Mark A. Hill

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Background.Delirium is a common syndrome affecting older people in hospital, whose pathophysiology is poorly understood, but sequelae of increased cognitive and functional impairment suggest neuronal loss.Methods.Cohort study comparing cerebrospinal fluid, blood, and clinical markers of delirium and neuronal cell death in 20 older hospitalized patients with delirium and 20 outpatients with Alzheimer's dementia.Results.Compared with participants with dementia, patients with delirium demonstrated higher CSF lactate (1.87 vs 1.48 mmol/L, p <. 001) and protein levels (0.62 vs 0.44 g/L, p =. 036) and lower levels of neuron-specific enolase (4.84 vs 8.98 ng/mL, p <. 001) but no difference in S100B. The changes correlated with clinical indices and outcomes.Conclusion.Older patients with delirium experience significant metabolic disturbance in the brain, which requires further investigation.

Original language	English
Pages (from-to)	1130-1136
Number of pages	7
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	65 A
Issue number	10
DOIs	https://doi.org/10.1093/gerona/glq090
Publication status	Published - Oct 2010
Externally published	Yes

Keywords

Delirium
Dementia
Lactic acid
Neuron-specific enolase
S100 proteins

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10.1093/gerona/glq090

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title = "Cerebrospinal fluid in long-lasting delirium compared with Alzheimer's dementia",

abstract = "Background.Delirium is a common syndrome affecting older people in hospital, whose pathophysiology is poorly understood, but sequelae of increased cognitive and functional impairment suggest neuronal loss.Methods.Cohort study comparing cerebrospinal fluid, blood, and clinical markers of delirium and neuronal cell death in 20 older hospitalized patients with delirium and 20 outpatients with Alzheimer's dementia.Results.Compared with participants with dementia, patients with delirium demonstrated higher CSF lactate (1.87 vs 1.48 mmol/L, p <. 001) and protein levels (0.62 vs 0.44 g/L, p =. 036) and lower levels of neuron-specific enolase (4.84 vs 8.98 ng/mL, p <. 001) but no difference in S100B. The changes correlated with clinical indices and outcomes.Conclusion.Older patients with delirium experience significant metabolic disturbance in the brain, which requires further investigation.",

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T1 - Cerebrospinal fluid in long-lasting delirium compared with Alzheimer's dementia

AU - Caplan, Gideon A.

AU - Kvelde, Tasha

AU - Lai, Christina

AU - Yap, Swee L.

AU - Lin, Cheryl

AU - Hill, Mark A.

PY - 2010/10

Y1 - 2010/10

N2 - Background.Delirium is a common syndrome affecting older people in hospital, whose pathophysiology is poorly understood, but sequelae of increased cognitive and functional impairment suggest neuronal loss.Methods.Cohort study comparing cerebrospinal fluid, blood, and clinical markers of delirium and neuronal cell death in 20 older hospitalized patients with delirium and 20 outpatients with Alzheimer's dementia.Results.Compared with participants with dementia, patients with delirium demonstrated higher CSF lactate (1.87 vs 1.48 mmol/L, p <. 001) and protein levels (0.62 vs 0.44 g/L, p =. 036) and lower levels of neuron-specific enolase (4.84 vs 8.98 ng/mL, p <. 001) but no difference in S100B. The changes correlated with clinical indices and outcomes.Conclusion.Older patients with delirium experience significant metabolic disturbance in the brain, which requires further investigation.

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KW - Lactic acid

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ER -

Cerebrospinal fluid in long-lasting delirium compared with Alzheimer's dementia

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Keywords

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