Challenges in chemotherapy delivery

comparison of standard chemotherapy delivery to locoregional vascular mass fluid transfer

Rodney J. Lane*, Nyan Y. Khin, Nick Pavlakis, Thomas J. Hugh, Stephen J. Clarke, John Magnussen, Chris Rogan, Roger L. Flekser

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)
29 Downloads (Pure)

Abstract

Standard intravenous chemotherapy delivery to neoplasms relies on simple diffusion gradients from the intravascular to the interstitial space. Systemic perfusion creates untoward effects on normal tissue limiting both concentration and exposure times. Regional intra-arterial therapy is limited by drug recirculation and vascular isolation repeatability and does not address the interstitial microenvironment. Barriers to delivery relate to chaotic vascular architecture, heterogeneous fluid flux, increased interstitial and variable solid tumor pressure and ischemia. To address these difficulties, a delivery system was developed allowing mass fluid transfer of chemotherapeutic agents into the interstitium. This implantable, reusable system is comprised of multiple independently steerable balloons and catheters capable of controlling the locoregional hydraulic and oncotic forces across the vascular endothelium.

Original languageEnglish
Pages (from-to)647-663
Number of pages17
JournalFuture Oncology
Volume14
Issue number7
DOIs
Publication statusPublished - 1 Mar 2018

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • bulk fluid flux
  • direct arterial chemotherapy delivery
  • drug eluding embolic particles
  • implantable multicatheter vascular access system
  • isolated hepatic infusion with recirculation and hemofiltration
  • mass fluid transfer
  • neoplasms
  • stop flow techniques
  • vascular mechanics

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