Challenges in chemotherapy delivery: comparison of standard chemotherapy delivery to locoregional vascular mass fluid transfer

Rodney J. Lane, Nyan Y. Khin, Nick Pavlakis, Thomas J. Hugh, Stephen J. Clarke, John Magnussen, Chris Rogan, Roger L. Flekser

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Standard intravenous chemotherapy delivery to neoplasms relies on simple diffusion gradients from the intravascular to the interstitial space. Systemic perfusion creates untoward effects on normal tissue limiting both concentration and exposure times. Regional intra-arterial therapy is limited by drug recirculation and vascular isolation repeatability and does not address the interstitial microenvironment. Barriers to delivery relate to chaotic vascular architecture, heterogeneous fluid flux, increased interstitial and variable solid tumor pressure and ischemia. To address these difficulties, a delivery system was developed allowing mass fluid transfer of chemotherapeutic agents into the interstitium. This implantable, reusable system is comprised of multiple independently steerable balloons and catheters capable of controlling the locoregional hydraulic and oncotic forces across the vascular endothelium.

LanguageEnglish
Pages647-663
Number of pages17
JournalFuture Oncology
Volume14
Issue number7
DOIs
Publication statusPublished - 1 Mar 2018

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Blood Vessels
Drug Therapy
Vascular Endothelium
Neoplasms
Ischemia
Catheters
Perfusion
Pressure
Pharmaceutical Preparations
Therapeutics

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Cite this

Lane, Rodney J. ; Khin, Nyan Y. ; Pavlakis, Nick ; Hugh, Thomas J. ; Clarke, Stephen J. ; Magnussen, John ; Rogan, Chris ; Flekser, Roger L. / Challenges in chemotherapy delivery : comparison of standard chemotherapy delivery to locoregional vascular mass fluid transfer. In: Future Oncology. 2018 ; Vol. 14, No. 7. pp. 647-663.
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Challenges in chemotherapy delivery : comparison of standard chemotherapy delivery to locoregional vascular mass fluid transfer. / Lane, Rodney J.; Khin, Nyan Y.; Pavlakis, Nick; Hugh, Thomas J.; Clarke, Stephen J.; Magnussen, John; Rogan, Chris; Flekser, Roger L.

In: Future Oncology, Vol. 14, No. 7, 01.03.2018, p. 647-663.

Research output: Contribution to journalArticleResearchpeer-review

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