Changes in circulating plasma met-enkephalin concentrations in feline intestinal ischemia-reperfusion

Anders Åneman; Sami Medbak; David Watson; Eva Haglind

doi:10.1007/BF02576373

Changes in circulating plasma met-enkephalin concentrations in feline intestinal ischemia-reperfusion

Anders Åneman, Sami Medbak, David Watson, Eva Haglind^*

^*Corresponding author for this work

Faculty of Medicine, Health and Human Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Plasma met-enkephalin-like immunoreactivity (MLI) levels were determined in cats before, during and after 90 min of intestinal ischemia followed by reperfusion and compared with the levels in control cats. Blood pressure and heart rate were registered and small intestinal mucosal lesions were graded. In control animals, the circulation was stable and there were no mucosal injuries. In the shock group, blood pressure decreased, heart rate increased and severe mucosal lesions were found. The circulating MLI levels were significantly higher 30 min after reperfusion of the ischemic intestine in the shock group than in the control group. There were correlations between MLI and tachycardia and hypotension respectively. Met-enkephalin was released in shock animals after reperfusion of the ischemic intestine and may explain naloxone responsiveness in intestinal shock models.

Original language	English
Pages (from-to)	129-138
Number of pages	10
Journal	Research in Experimental Medicine
Volume	194
Issue number	1
DOIs	https://doi.org/10.1007/BF02576373
Publication status	Published - Dec 1994

Keywords

Intestinal ischemia
Met-enkephalin
Mucosal lesion
Reperfusion
Shock

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10.1007/BF02576373

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title = "Changes in circulating plasma met-enkephalin concentrations in feline intestinal ischemia-reperfusion",

abstract = "Plasma met-enkephalin-like immunoreactivity (MLI) levels were determined in cats before, during and after 90 min of intestinal ischemia followed by reperfusion and compared with the levels in control cats. Blood pressure and heart rate were registered and small intestinal mucosal lesions were graded. In control animals, the circulation was stable and there were no mucosal injuries. In the shock group, blood pressure decreased, heart rate increased and severe mucosal lesions were found. The circulating MLI levels were significantly higher 30 min after reperfusion of the ischemic intestine in the shock group than in the control group. There were correlations between MLI and tachycardia and hypotension respectively. Met-enkephalin was released in shock animals after reperfusion of the ischemic intestine and may explain naloxone responsiveness in intestinal shock models.",

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AU - Åneman, Anders

AU - Medbak, Sami

AU - Watson, David

AU - Haglind, Eva

PY - 1994/12

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N2 - Plasma met-enkephalin-like immunoreactivity (MLI) levels were determined in cats before, during and after 90 min of intestinal ischemia followed by reperfusion and compared with the levels in control cats. Blood pressure and heart rate were registered and small intestinal mucosal lesions were graded. In control animals, the circulation was stable and there were no mucosal injuries. In the shock group, blood pressure decreased, heart rate increased and severe mucosal lesions were found. The circulating MLI levels were significantly higher 30 min after reperfusion of the ischemic intestine in the shock group than in the control group. There were correlations between MLI and tachycardia and hypotension respectively. Met-enkephalin was released in shock animals after reperfusion of the ischemic intestine and may explain naloxone responsiveness in intestinal shock models.

AB - Plasma met-enkephalin-like immunoreactivity (MLI) levels were determined in cats before, during and after 90 min of intestinal ischemia followed by reperfusion and compared with the levels in control cats. Blood pressure and heart rate were registered and small intestinal mucosal lesions were graded. In control animals, the circulation was stable and there were no mucosal injuries. In the shock group, blood pressure decreased, heart rate increased and severe mucosal lesions were found. The circulating MLI levels were significantly higher 30 min after reperfusion of the ischemic intestine in the shock group than in the control group. There were correlations between MLI and tachycardia and hypotension respectively. Met-enkephalin was released in shock animals after reperfusion of the ischemic intestine and may explain naloxone responsiveness in intestinal shock models.

KW - Intestinal ischemia

KW - Met-enkephalin

KW - Mucosal lesion

KW - Reperfusion

KW - Shock

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Changes in circulating plasma met-enkephalin concentrations in feline intestinal ischemia-reperfusion

Abstract

Keywords

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