Abstract
In this paper, the mechanism of the penicillin G anaphylactic reaction was studied. Rats were sensitized to penicilloyl (BPO)-protein. The incidences of anaphylactic reaction and death were 100 and 40%, respectively. After being challenged, the degranulation rates of rat cranial periosteous and peritoneal mast cells were 91 +/- 5 and 44 +/- 10%, respectively. In the control group, they were 11 +/- 5 and 7 +/- 2%, respectively. The histamine release rates from sensitized and control rat peritoneal mast cells were 13 +/- 2 and 3.0 +/- 0.4%, respectively. The passive cutaneous anaphylaxis (PCA) test demonstrated that the antibody titers in sensitized serum were 16-32.
| Translated title of the contribution | Changes in degranulation and histamine release from mast cells in rats sensitized by penicilloyl-protein |
|---|---|
| Original language | Chinese |
| Pages (from-to) | 78-81 |
| Number of pages | 4 |
| Journal | Acta Pharmacologica Sinica |
| Volume | 10 |
| Issue number | 1 |
| Publication status | Published - 1989 |
| Externally published | Yes |
Bibliographical note
青霉噻唑蛋白致敏大鼠肥大细肥脱颗粒及组胺释放的变化Keywords
- penicillin G
- penicillol-protein
- immunization
- mast cells
- histamine