qīng méi sāi zuò dàn bái zhì mǐn dà shǔ féi dà xì féi tuō kē lì jí zǔ àn shì fàng de biàn huà

Translated title of the contribution: Changes in degranulation and histamine release from mast cells in rats sensitized by penicilloyl-protein

Zhen-Jun Zhao, Tong-Xun Ma

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper, the mechanism of the penicillin G anaphylactic reaction was studied. Rats were sensitized to penicilloyl (BPO)-protein. The incidences of anaphylactic reaction and death were 100 and 40%, respectively. After being challenged, the degranulation rates of rat cranial periosteous and peritoneal mast cells were 91 +/- 5 and 44 +/- 10%, respectively. In the control group, they were 11 +/- 5 and 7 +/- 2%, respectively. The histamine release rates from sensitized and control rat peritoneal mast cells were 13 +/- 2 and 3.0 +/- 0.4%, respectively. The passive cutaneous anaphylaxis (PCA) test demonstrated that the antibody titers in sensitized serum were 16-32.
Translated title of the contributionChanges in degranulation and histamine release from mast cells in rats sensitized by penicilloyl-protein
Original languageChinese
Pages (from-to)78-81
Number of pages4
JournalActa Pharmacologica Sinica
Volume10
Issue number1
Publication statusPublished - 1989
Externally publishedYes

Bibliographical note

青霉噻唑蛋白致敏大鼠肥大细肥脱颗粒及组胺释放的变化

Keywords

  • penicillin G
  • penicillol-protein
  • immunization
  • mast cells
  • histamine

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