The KYN pathway (KP) is the main catabolic pathway of the essential amino acid TRP. The KP has been identifi ed as playing critical roles in the regulation of the immune response in a variety of experimental settings. It is also known to be involved in several neuroinfl ammatory diseases including Huntington’s disease, amyotrophic lateral sclerosis and Alzheimer’s disease. This chapter considers the current understanding of the role of the KP in stem cell biology. Both these fundamental areas of cell biology have independently been the focus of a burgeoning research interest in recent years. However, little is known about how these two important fi elds of research interact. Several of the infl ammatory and infectious diseases in which the KP has been implicated include those for which stem cell therapies are being actively explored at a clinical level. Therefore, it is highly pertinent to consider the evidence that the KP infl uences stem cell biology and impacts on the functional behaviour of progenitor cells.
|Title of host publication||Targeting the Broadly Pathogenic Kynurenine Pathway|
|Place of Publication||Cham|
|Publisher||Springer, Springer Nature|
|Number of pages||16|
|Publication status||Published - 1 Jan 2015|