Chapter 20

Role of the kynurenine pathway in stem cell biology

Simon P. Jones*, Gilles J. Guillemin, Bruce J. Brew

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    The KYN pathway (KP) is the main catabolic pathway of the essential amino acid TRP. The KP has been identifi ed as playing critical roles in the regulation of the immune response in a variety of experimental settings. It is also known to be involved in several neuroinfl ammatory diseases including Huntington’s disease, amyotrophic lateral sclerosis and Alzheimer’s disease. This chapter considers the current understanding of the role of the KP in stem cell biology. Both these fundamental areas of cell biology have independently been the focus of a burgeoning research interest in recent years. However, little is known about how these two important fi elds of research interact. Several of the infl ammatory and infectious diseases in which the KP has been implicated include those for which stem cell therapies are being actively explored at a clinical level. Therefore, it is highly pertinent to consider the evidence that the KP infl uences stem cell biology and impacts on the functional behaviour of progenitor cells.

    Original languageEnglish
    Title of host publicationTargeting the Broadly Pathogenic Kynurenine Pathway
    EditorsSandeep Mittal
    Place of PublicationCham
    PublisherSpringer, Springer Nature
    Pages257-272
    Number of pages16
    ISBN (Electronic)9783319118703
    ISBN (Print)9783319118697
    DOIs
    Publication statusPublished - 1 Jan 2015

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