Characterisation of a novel UV filter in the lens of the thirteen-lined ground squirrel (Ictidomys tridecemlineatus)

Brian Lyons; Peter Karuso; Joanne F. Jamie; Mukoma F. Simpanya; Frank Giblin; Roger J W Truscott

doi:10.1016/j.exer.2014.01.022

Characterisation of a novel UV filter in the lens of the thirteen-lined ground squirrel (Ictidomys tridecemlineatus)

Brian Lyons, Peter Karuso, Joanne F. Jamie, Mukoma F. Simpanya, Frank Giblin, Roger J W Truscott^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Structural analysis of a novel UV filter present in the lens of the thirteen-lined ground squirrel has shown that it is related in structure to N-acetyl-3-hydroxykynurenine. This finding is consistent with the fact that the squirrel lenses also contain high levels of this tryptophan metabolite. Analysis of both NMR and mass spectrometric data suggested that the novel UV filter compound forms by condensation of proline with N-acetyl-3-hydroxykynurenine. Its absorption maximum at 340nm is more than 20nm lower than that of the kynurenines and it may therefore assist in filtering the more damaging shorter wavelengths of UVA.

Original language	English
Pages (from-to)	114-120
Number of pages	7
Journal	Experimental Eye Research
Volume	121
DOIs	https://doi.org/10.1016/j.exer.2014.01.022
Publication status	Published - Apr 2014

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10.1016/j.exer.2014.01.022

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title = "Characterisation of a novel UV filter in the lens of the thirteen-lined ground squirrel (Ictidomys tridecemlineatus)",

abstract = "Structural analysis of a novel UV filter present in the lens of the thirteen-lined ground squirrel has shown that it is related in structure to N-acetyl-3-hydroxykynurenine. This finding is consistent with the fact that the squirrel lenses also contain high levels of this tryptophan metabolite. Analysis of both NMR and mass spectrometric data suggested that the novel UV filter compound forms by condensation of proline with N-acetyl-3-hydroxykynurenine. Its absorption maximum at 340nm is more than 20nm lower than that of the kynurenines and it may therefore assist in filtering the more damaging shorter wavelengths of UVA.",

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AU - Lyons, Brian

AU - Karuso, Peter

AU - Jamie, Joanne F.

AU - Simpanya, Mukoma F.

AU - Giblin, Frank

AU - Truscott, Roger J W

PY - 2014/4

Y1 - 2014/4

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AB - Structural analysis of a novel UV filter present in the lens of the thirteen-lined ground squirrel has shown that it is related in structure to N-acetyl-3-hydroxykynurenine. This finding is consistent with the fact that the squirrel lenses also contain high levels of this tryptophan metabolite. Analysis of both NMR and mass spectrometric data suggested that the novel UV filter compound forms by condensation of proline with N-acetyl-3-hydroxykynurenine. Its absorption maximum at 340nm is more than 20nm lower than that of the kynurenines and it may therefore assist in filtering the more damaging shorter wavelengths of UVA.

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JO - Experimental Eye Research

JF - Experimental Eye Research

ER -

Characterisation of a novel UV filter in the lens of the thirteen-lined ground squirrel (Ictidomys tridecemlineatus)

Abstract

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