Characterisation of a novel UV filter in the lens of the thirteen-lined ground squirrel (Ictidomys tridecemlineatus)

Brian Lyons, Peter Karuso, Joanne F. Jamie, Mukoma F. Simpanya, Frank Giblin, Roger J W Truscott*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Structural analysis of a novel UV filter present in the lens of the thirteen-lined ground squirrel has shown that it is related in structure to N-acetyl-3-hydroxykynurenine. This finding is consistent with the fact that the squirrel lenses also contain high levels of this tryptophan metabolite. Analysis of both NMR and mass spectrometric data suggested that the novel UV filter compound forms by condensation of proline with N-acetyl-3-hydroxykynurenine. Its absorption maximum at 340nm is more than 20nm lower than that of the kynurenines and it may therefore assist in filtering the more damaging shorter wavelengths of UVA.

Original languageEnglish
Pages (from-to)114-120
Number of pages7
JournalExperimental Eye Research
Volume121
DOIs
Publication statusPublished - 2014

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