Characterisation of cardiac autonomic function in multiple sclerosis based on spontaneous changes of heart rate and blood pressure

Fatemeh Shirbani, Edward Barin, Yi Ching Lee, Karl Ng, John Douglas Edward Parratt, Mark Butlin, Alberto P. Avolio

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Prevalence of cardiovascular autonomic dysfunction (CAD) in multiple sclerosis (MS) varies between studies. Cardiac autonomic function is usually assessed by cardiovascular reflex tests. We hypothesized that MS is associated with CAD, quantifiable by non-invasive means including quantification of baroreceptor sensitivity (BRS) and heart rate variability. Methods: In this study a comprehensive suite of cardiovascular autonomic tests based only on the spontaneous changes of heart rate and blood pressure was applied to 23 MS patients and age and gender-matched controls. From 5-min continuous non-invasive recording of the electrocardiogram and blood pressure, heart-rate, blood pressure, and autonomic function variables were calculated. Analysis included heart rate variability in the time domain, heart rate and blood pressure variability in the frequency domain, and baroreceptor sensitivity in both the time and frequency domain. Results: BRS measured by the frequency technique in high frequency band was found to be significantly lower in MS (16 ± 9 ms/mmHg) compared to controls (29 ± 17 ms/mmHg) (p < 0.05). Also mean of BRS modulus in MS averaged 15 ± 8 ms/mmHg which is significantly lower compared to controls (25 ± 15 ms/mmHg) (p < 0.05). Systolic blood pressure variability in the high frequency band (0.15–0.5 Hz) was found to be significantly higher in the MS compared to controls (5.8 ± 16.7 mmHg2 vs. 1.3 ± 0.8 mmHg2) (p < 0.05). Conclusions: The results, using techniques novel to MS investigation, showed diminished baroreceptor reflex and impaired sympathetic function using frequency domain systolic blood pressure variability analysis.

LanguageEnglish
Pages120-127
Number of pages8
JournalMultiple Sclerosis and Related Disorders
Volume22
DOIs
Publication statusPublished - 1 May 2018

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Multiple Sclerosis
Heart Rate
Blood Pressure
Pressoreceptors
Baroreflex
Reflex
Electrocardiography

Keywords

  • Baroreceptor sensitivity
  • Cardiac autonomic dysfunction
  • Heart rate variability
  • Multiple sclerosis
  • Parasympathetic functions
  • Sympathetic function

Cite this

@article{3238631f153d4788bc76446d2b1b8327,
title = "Characterisation of cardiac autonomic function in multiple sclerosis based on spontaneous changes of heart rate and blood pressure",
abstract = "Background: Prevalence of cardiovascular autonomic dysfunction (CAD) in multiple sclerosis (MS) varies between studies. Cardiac autonomic function is usually assessed by cardiovascular reflex tests. We hypothesized that MS is associated with CAD, quantifiable by non-invasive means including quantification of baroreceptor sensitivity (BRS) and heart rate variability. Methods: In this study a comprehensive suite of cardiovascular autonomic tests based only on the spontaneous changes of heart rate and blood pressure was applied to 23 MS patients and age and gender-matched controls. From 5-min continuous non-invasive recording of the electrocardiogram and blood pressure, heart-rate, blood pressure, and autonomic function variables were calculated. Analysis included heart rate variability in the time domain, heart rate and blood pressure variability in the frequency domain, and baroreceptor sensitivity in both the time and frequency domain. Results: BRS measured by the frequency technique in high frequency band was found to be significantly lower in MS (16 ± 9 ms/mmHg) compared to controls (29 ± 17 ms/mmHg) (p < 0.05). Also mean of BRS modulus in MS averaged 15 ± 8 ms/mmHg which is significantly lower compared to controls (25 ± 15 ms/mmHg) (p < 0.05). Systolic blood pressure variability in the high frequency band (0.15–0.5 Hz) was found to be significantly higher in the MS compared to controls (5.8 ± 16.7 mmHg2 vs. 1.3 ± 0.8 mmHg2) (p < 0.05). Conclusions: The results, using techniques novel to MS investigation, showed diminished baroreceptor reflex and impaired sympathetic function using frequency domain systolic blood pressure variability analysis.",
keywords = "Baroreceptor sensitivity, Cardiac autonomic dysfunction, Heart rate variability, Multiple sclerosis, Parasympathetic functions, Sympathetic function",
author = "Fatemeh Shirbani and Edward Barin and Lee, {Yi Ching} and Karl Ng and Parratt, {John Douglas Edward} and Mark Butlin and Avolio, {Alberto P.}",
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Characterisation of cardiac autonomic function in multiple sclerosis based on spontaneous changes of heart rate and blood pressure. / Shirbani, Fatemeh; Barin, Edward; Lee, Yi Ching; Ng, Karl; Parratt, John Douglas Edward; Butlin, Mark; Avolio, Alberto P.

In: Multiple Sclerosis and Related Disorders, Vol. 22, 01.05.2018, p. 120-127.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Characterisation of cardiac autonomic function in multiple sclerosis based on spontaneous changes of heart rate and blood pressure

AU - Shirbani, Fatemeh

AU - Barin, Edward

AU - Lee, Yi Ching

AU - Ng, Karl

AU - Parratt, John Douglas Edward

AU - Butlin, Mark

AU - Avolio, Alberto P.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background: Prevalence of cardiovascular autonomic dysfunction (CAD) in multiple sclerosis (MS) varies between studies. Cardiac autonomic function is usually assessed by cardiovascular reflex tests. We hypothesized that MS is associated with CAD, quantifiable by non-invasive means including quantification of baroreceptor sensitivity (BRS) and heart rate variability. Methods: In this study a comprehensive suite of cardiovascular autonomic tests based only on the spontaneous changes of heart rate and blood pressure was applied to 23 MS patients and age and gender-matched controls. From 5-min continuous non-invasive recording of the electrocardiogram and blood pressure, heart-rate, blood pressure, and autonomic function variables were calculated. Analysis included heart rate variability in the time domain, heart rate and blood pressure variability in the frequency domain, and baroreceptor sensitivity in both the time and frequency domain. Results: BRS measured by the frequency technique in high frequency band was found to be significantly lower in MS (16 ± 9 ms/mmHg) compared to controls (29 ± 17 ms/mmHg) (p < 0.05). Also mean of BRS modulus in MS averaged 15 ± 8 ms/mmHg which is significantly lower compared to controls (25 ± 15 ms/mmHg) (p < 0.05). Systolic blood pressure variability in the high frequency band (0.15–0.5 Hz) was found to be significantly higher in the MS compared to controls (5.8 ± 16.7 mmHg2 vs. 1.3 ± 0.8 mmHg2) (p < 0.05). Conclusions: The results, using techniques novel to MS investigation, showed diminished baroreceptor reflex and impaired sympathetic function using frequency domain systolic blood pressure variability analysis.

AB - Background: Prevalence of cardiovascular autonomic dysfunction (CAD) in multiple sclerosis (MS) varies between studies. Cardiac autonomic function is usually assessed by cardiovascular reflex tests. We hypothesized that MS is associated with CAD, quantifiable by non-invasive means including quantification of baroreceptor sensitivity (BRS) and heart rate variability. Methods: In this study a comprehensive suite of cardiovascular autonomic tests based only on the spontaneous changes of heart rate and blood pressure was applied to 23 MS patients and age and gender-matched controls. From 5-min continuous non-invasive recording of the electrocardiogram and blood pressure, heart-rate, blood pressure, and autonomic function variables were calculated. Analysis included heart rate variability in the time domain, heart rate and blood pressure variability in the frequency domain, and baroreceptor sensitivity in both the time and frequency domain. Results: BRS measured by the frequency technique in high frequency band was found to be significantly lower in MS (16 ± 9 ms/mmHg) compared to controls (29 ± 17 ms/mmHg) (p < 0.05). Also mean of BRS modulus in MS averaged 15 ± 8 ms/mmHg which is significantly lower compared to controls (25 ± 15 ms/mmHg) (p < 0.05). Systolic blood pressure variability in the high frequency band (0.15–0.5 Hz) was found to be significantly higher in the MS compared to controls (5.8 ± 16.7 mmHg2 vs. 1.3 ± 0.8 mmHg2) (p < 0.05). Conclusions: The results, using techniques novel to MS investigation, showed diminished baroreceptor reflex and impaired sympathetic function using frequency domain systolic blood pressure variability analysis.

KW - Baroreceptor sensitivity

KW - Cardiac autonomic dysfunction

KW - Heart rate variability

KW - Multiple sclerosis

KW - Parasympathetic functions

KW - Sympathetic function

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U2 - 10.1016/j.msard.2018.03.018

DO - 10.1016/j.msard.2018.03.018

M3 - Article

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JO - Multiple Sclerosis and Related Disorders

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JF - Multiple Sclerosis and Related Disorders

SN - 2211-0348

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