Characterisation of major histocompatibility complex class I in the Australian cane toad, Rhinella marina

Mette Lillie, Richard Shine, Katherine Belov

Research output: Contribution to journalArticle

16 Citations (Scopus)
1 Downloads (Pure)

Abstract

The Major Histocompatibility Complex (MHC) class I is a highly variable gene family that encodes cell-surface receptors vital for recognition of intracellular pathogens and initiation of immune responses. The MHC class I has yet to be characterised in bufonid toads (Order: Anura; Suborder: Neobatrachia; Family: Bufonidae), a large and diverse family of anurans. Here we describe the characterisation of a classical MHC class I gene in the Australian cane toad, Rhinella marina. From 25 individuals sampled from the Australian population, we found only 3 alleles at this classical class I locus. We also found large number of class I alpha 1 alleles, implying an expansion of class I loci in this species. The low classical class I genetic diversity is likely the result of repeated bottleneck events, which arose as a result of the cane toad's complex history of introductions as a biocontrol agent and its subsequent invasion across Australia.

Original languageEnglish
Article numbere102824
Pages (from-to)1-9
Number of pages9
JournalPLoS ONE
Volume9
Issue number8
DOIs
Publication statusPublished - 5 Aug 2014
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Fingerprint Dive into the research topics of 'Characterisation of major histocompatibility complex class I in the Australian cane toad, <i>Rhinella marina</i>'. Together they form a unique fingerprint.

  • Cite this