Characteristics and outcome for heart failure patients with mid-range ejection fraction

Nelson Wang, Susan Hales, Edward Barin, Geoffrey Tofler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Aims: The aim of this study was to compare precipitants, presenting symptoms and outcomes of patients with heart failure and mid-range ejection fraction (HFmrEF), heart failure and preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) in an Australian cohort. Methods: We divided 5236 patients in the Management of Cardiac Failure program in Northern Sydney Australia, into HFmrEF (n=780, 14.9%), HFpEF (n=1956, 37.4%) and HFrEF (n=2500, 47.8%), using a cutoff left ventricular ejection fraction of 40-49, at least 50 and less than 40%, respectively. Results: For most characteristics, the HFmrEF patients were intermediate. Hypertension among the HFrEF, HFmrEF and HFpEF groups was present in 50.6, 61.7 and 68.9%, respectively; age more than 85 years was present in 35.1, 37.6 and 42.2%; atrial fibrillation in 35.3, 44.2 and 49.9%; and elevated serum creatinine (>100μmol/l) in 59.2, 55.6 and 51.0%. For ischemic heart disease and ischemia as a precipitant of admission, HFmrEF patients were similar to the HFrEF group, and more common than in HFpEF. Mortality rates were not significantly different between the three groups. Readmission rates were highest for HFpEF (40.2%), followed by HFmrEF (42.4%) and HFrEF (45.4%), largely due to differences in nonheart failure readmission. Conclusion: Clinically, HFmrEF represents an intermediate phenotype, with the exception of resembling HFrEF with a higher incidence of ischemic heart disease.

Original languageEnglish
Pages (from-to)297-303
Number of pages7
JournalJournal of Cardiovascular Medicine
Issue number6
Publication statusPublished - 1 Jun 2018
Externally publishedYes


  • Cardiac function
  • Heart failure
  • Mid-range

Fingerprint Dive into the research topics of 'Characteristics and outcome for heart failure patients with mid-range ejection fraction'. Together they form a unique fingerprint.

Cite this