Characteristics and outcomes of COVID‐19 pneumonia in pregnancy compared with infected nonpregnant women

Maryam Vizheh, Salut Muhidin, Faezeh Aghajani, Zohreh Maleki, Fareshteh Bagheri, Hadiseh Hosamirudsari, Ashraf Aleyasin, Afsaneh Tehranian*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To compare the clinical and paraclinical features and outcomes of pregnant and nonpregnant women with COVID-19. Methods: A multicenter retrospective cohort study of pregnant and nonpregnant women of reproductive age hospitalized between March and October 2020 in Tehran, Iran. Medical records were reviewed and women who tested positive for SARS-CoV-2 on RT-PCR were included. Extracted data were compared and logistic regression performed. Results: A total of 110 pregnant and 234 nonpregnant COVID-19-positive women were included. Frequency of severe disease was higher in nonpregnant women than pregnant women (29% vs 11.8%; P < 0.001). Symptoms including cough, dyspnea, chill, fatigue, and headache were more frequent in nonpregnant women (P < 0.05). Pregnant women had higher oxygen saturation levels and lower lymphocyte count (P = 0.001). Six (5.5%) pregnant and 12 (5.1%) nonpregnant women died (P = 0.80). No significant differences between the groups were found for ICU admission and end organ failure. Significantly more nonpregnant women had acute respiratory distress syndrome (ARDS, 9.4% vs 0%; P = 0.001). Univariate regression indicated association between hypertension and death; oxygen saturation and ARDS; and body mass index and ICU admission. No association was found between pregnancy and death, ICU admission, or ARDS. Conclusion: Pregnant women with COVID-19 are not at higher risk of adverse outcomes compared with nonpregnant women.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalInternational Journal of Gynecology and Obstetrics
DOIs
Publication statusE-pub ahead of print - 8 Apr 2021

Keywords

  • COVID-19
  • pneumonia
  • pregnancy
  • pregnancy outcomes
  • severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

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