Characteristics of equine herpesvirus 1 glycoproteins expressed in insect cells

J. Millar Whalley*, Daria N. Love, Deepanker Tewari, Hugh J. Field

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)


    A series of recombinant baculoviruses containing genes for glycoproteins C, D, H and L of equine herpesvirus 1 (EHV-1) have been constructed, and the EHV-1 products characterised by gel electrophoresis and immunoblotting. The EHV-1 glycoproteins expressed in insect cells were similar but not identical in apparent sizes to those expressed in EHV-1 infected mammalian cells. Each of the EHV-1 products was recognised by convalescent equine sera, indicating that they were all targets for an equine immune response. Mice immunised with baculovirus-expressed EHV-1 gD and gC acquired an enhanced ability to clear challenge EHV-1 from respiratory tissues, in association with both neutralising antibody and cell mediated immune responses.

    Original languageEnglish
    Pages (from-to)193-201
    Number of pages9
    JournalVeterinary Microbiology
    Issue number1-3
    Publication statusPublished - 1995


    • Equine herpesvirus 1
    • Glycoproteins
    • Immune responses
    • Mouse model
    • Recombinant baculoviruses


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