Abstract
Aim: To compare the characteristics of patients with uncontrolled asthma
across multiple urban regions of Australia.
Methods: Adults (non/ex-smokers) with symptomatic asthma despite main-
tenance ICS/LABA treatment (n = 248) were assessed for the AMAZES study,
a multicentre RCT evaluating the addition of azithromycin in fi ve tertiary
centres: John Hunter (JHH), Princess Alexandra (PAH), Royal Adelaide
(RAH), Prince Charles (TPCH) and Sir Charles Gairdner (SCGH) Hospitals.
Clinical assessment and sputum induction were performed.
Results: Participants had a mean (SD) age of 58 (13) years, pre β2 FEV1%
71.9 (22.4), FEV1/FVC 68.4 (12.3) and asthma control questionnaire score
1.82 (0.86) with no signifi cant differences between centres. There were differ-
ences in asthma severity with fewer participants at GINA treatment step 4 (p
= 0.001) and lower maintenance ICS dose (p = 0.002) from PAH and RAH.
Participants from RAH were significantly more sensitive to grass (p = 0.006)
and cat hair (p < 0.001) specific allergen, and RAH and SCGH participants
more likely to experience hay fever (p < 0.0001). Work was reported as a
significant trigger for asthma in JHH participants (p = 0.024), while rhinitis was
significantly less of a trigger (p = 0.001). There were no differences in smoking
history, sputum phenotype, blood eosinophilia or symptom visual analogue
scores between centres.
Conclusions: Participants with uncontrolled asthma have similar lung function and smoking history but differ in GINA treatment step, specific allergen
sensitivity and asthma triggers across Australia.
| Original language | English |
|---|---|
| Article number | P017 |
| Pages (from-to) | 42-42 |
| Number of pages | 1 |
| Journal | Respirology |
| Volume | 18 |
| Issue number | Supplement 2 |
| Publication status | Published - Apr 2013 |
| Externally published | Yes |