Characteristics of uncontrolled asthma in Australia

Amazes Study Research Group

Research output: Contribution to journalMeeting abstractpeer-review


Aim: To compare the characteristics of patients with uncontrolled asthma across multiple urban regions of Australia. Methods: Adults (non/ex-smokers) with symptomatic asthma despite main- tenance ICS/LABA treatment (n = 248) were assessed for the AMAZES study, a multicentre RCT evaluating the addition of azithromycin in fi ve tertiary centres: John Hunter (JHH), Princess Alexandra (PAH), Royal Adelaide (RAH), Prince Charles (TPCH) and Sir Charles Gairdner (SCGH) Hospitals. Clinical assessment and sputum induction were performed. Results: Participants had a mean (SD) age of 58 (13) years, pre β2 FEV1% 71.9 (22.4), FEV1/FVC 68.4 (12.3) and asthma control questionnaire score 1.82 (0.86) with no signifi cant differences between centres. There were differ- ences in asthma severity with fewer participants at GINA treatment step 4 (p = 0.001) and lower maintenance ICS dose (p = 0.002) from PAH and RAH. Participants from RAH were significantly more sensitive to grass (p = 0.006) and cat hair (p < 0.001) specific allergen, and RAH and SCGH participants more likely to experience hay fever (p < 0.0001). Work was reported as a significant trigger for asthma in JHH participants (p = 0.024), while rhinitis was significantly less of a trigger (p = 0.001). There were no differences in smoking history, sputum phenotype, blood eosinophilia or symptom visual analogue scores between centres. Conclusions: Participants with uncontrolled asthma have similar lung function and smoking history but differ in GINA treatment step, specific allergen sensitivity and asthma triggers across Australia.
Original languageEnglish
Article numberP017
Pages (from-to)42-42
Number of pages1
Issue numberSupplement 2
Publication statusPublished - Apr 2013
Externally publishedYes


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