Characterization of the earliest known Staphylococcus aureus plasmid encoding a multidrug efflux system

Ian T. Paulsen, Melissa H. Brown, Ronald A. Skurray*

*Corresponding author for this work

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The staphylococcal qacB-encoding multidrug resistance plasmid pSK156, isolated from a clinical strain dating from 1951, was characterized. Comparison of the regions flanking qacB with other qacA- and qacB-encoding plasmids provided insights into the evolution and dissemination of these multidrug efflux genes and led to the detection of the earliest known copy of the insertion sequence IS257.

Original languageEnglish
Pages (from-to)3477-3479
Number of pages3
JournalJournal of Bacteriology
Volume180
Issue number13
Publication statusPublished - Jul 1998
Externally publishedYes

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