TY - GEN
T1 - Characterization of the surface physico-chemical stability of materials directly applicable to inhalation therapy
AU - Begat, P.
AU - Kattige, A.
AU - Price, R.
AU - Young, P. M.
PY - 2003
Y1 - 2003
N2 - Atomic force microscopy (AFM) has been used to investigate the surface properties of mechanically processed respirable sized drug particles. Phase imaging, an auxiliary technique of conventional intermittent contact mode Tapping Model AFM imaging, was employed to differentiate the physico-mechanical variations on the processed surfaces of model salbutamol sulphate drug crystals. Samples were produced by cumulative milling of crystals formed by conventional batch crystallisation. With increased periods of milling, specific regions on the salbutamol sulphate crystals showed increased variations in phase lag (<30/spl deg/), which were independent of topographical induced phase changes. These regions, not generally observed on nonmilled samples, suggested a surface induced change to the physico-mechanical properties of the processed crystals. The surface regions of increased phase could possibly be associated with the formation of surface disorder, which could be amorphous in nature.
AB - Atomic force microscopy (AFM) has been used to investigate the surface properties of mechanically processed respirable sized drug particles. Phase imaging, an auxiliary technique of conventional intermittent contact mode Tapping Model AFM imaging, was employed to differentiate the physico-mechanical variations on the processed surfaces of model salbutamol sulphate drug crystals. Samples were produced by cumulative milling of crystals formed by conventional batch crystallisation. With increased periods of milling, specific regions on the salbutamol sulphate crystals showed increased variations in phase lag (<30/spl deg/), which were independent of topographical induced phase changes. These regions, not generally observed on nonmilled samples, suggested a surface induced change to the physico-mechanical properties of the processed crystals. The surface regions of increased phase could possibly be associated with the formation of surface disorder, which could be amorphous in nature.
UR - http://www.scopus.com/inward/record.url?scp=1542330191&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2003.1281010
DO - 10.1109/IEMBS.2003.1281010
M3 - Conference proceeding contribution
SN - 0780377893
SN - 9780780377899
T3 - Proceedings of the annual international conference of the IEEE Engineering in Medicine and Biology Society
SP - 3873
EP - 3875
BT - Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - Institute of Electrical and Electronics Engineers (IEEE)
CY - Piscataway, NJ
T2 - Annual International Conference of the IEEE Engineering in Medicine and Biology Society (25th : 2003)
Y2 - 17 September 2003 through 19 September 2003
ER -