Characterization of the surface physico-chemical stability of materials directly applicable to inhalation therapy

P. Begat, A. Kattige, R. Price, P. M. Young

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

Abstract

Atomic force microscopy (AFM) has been used to investigate the surface properties of mechanically processed respirable sized drug particles. Phase imaging, an auxiliary technique of conventional intermittent contact mode Tapping Model AFM imaging, was employed to differentiate the physico-mechanical variations on the processed surfaces of model salbutamol sulphate drug crystals. Samples were produced by cumulative milling of crystals formed by conventional batch crystallisation. With increased periods of milling, specific regions on the salbutamol sulphate crystals showed increased variations in phase lag (<30/spl deg/), which were independent of topographical induced phase changes. These regions, not generally observed on nonmilled samples, suggested a surface induced change to the physico-mechanical properties of the processed crystals. The surface regions of increased phase could possibly be associated with the formation of surface disorder, which could be amorphous in nature.
Original languageEnglish
Title of host publicationProceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationa new beginning for human health : 17-21 September, 2003, Cancún, Mexico
Place of PublicationPiscataway, NJ
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages3873-3875
Number of pages3
ISBN (Print)0780377893, 9780780377899
DOIs
Publication statusPublished - 2003
Externally publishedYes
EventAnnual International Conference of the IEEE Engineering in Medicine and Biology Society (25th : 2003) - Cancun, Mexico
Duration: 17 Sep 200319 Sep 2003

Publication series

NameProceedings of the annual international conference of the IEEE Engineering in Medicine and Biology Society
ISSN (Print)1094-687X

Conference

ConferenceAnnual International Conference of the IEEE Engineering in Medicine and Biology Society (25th : 2003)
CountryMexico
CityCancun
Period17/09/0319/09/03

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