Chemotherapy-induced cognitive impairments: white matter pathologies

A. Matsos*, M. Loomes, I. Zhou, E. Macmillan, I. Sabel, E. Rotziokos, W. Beckwith, I. N. Johnston

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Whilst chemotherapeutic agents show promising results in the amelioration of cancerous tumors, patients often experience cognitive disturbances associated with chemotherapy long after treatment has ceased. Research has suggested that the structural integrity of white matter fibres in the brain are susceptible to the harmful effects of chemotherapy. Post-chemotherapy, white matter tracts often display altered morphology with a reduction in glial cells such as oligodendrocytes. Demyelination, gliosis and leukoencephalopathy during or post chemotherapy is associated with changes in processing speed and IQ. Thus, understanding the relationship between chemotherapy, white matter damage and cognition is warranted. This review presents evidence for chemotherapy induced white matter damage highlighting the importance of implementing behavioral and pharmological strategies to prevent or reverse such acute toxicity in the brain.
Original languageEnglish
Pages (from-to)6–14
Number of pages9
JournalCancer Treatment Reviews
Volume61
DOIs
Publication statusPublished - Dec 2017
Externally publishedYes

Keywords

  • cancer
  • chemotherapy
  • white matter
  • myelin
  • corpus callosum and processing speed

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