Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas

a multicenter study

A. Y. Zhang*, I. Judson, C. Benson, J. S. Wunder, I. Ray-Coquard, R. J. Grimer, R. Quek, E. Wong, A. B. Miah, P. C. Ferguson, A. Dufresne, J. Y. H. Teh, M. Stockler, M. H. N. Tattersall

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Citations (Scopus)
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Background: An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated with a reduced time to development of RIS. We now present a multi-centre collaborative study to validate this association. Methods: This was a retrospective cohort study of RIS cases across five large international sarcoma centres between 1 January 2000 to 31 December 2014. The primary endpoint was time to development of RIS. Results: We identified 419 patients with RIS. Chemotherapy for the first malignancy was associated with a shorter time to RIS development (HR 1.37; 95% CI: 1.08-1.72; P=0.009). In the multi-variable model, older age (HR 2.11; 95% CI 1.83-2.43; P<0.001) and chemotherapy for the first malignancy (HR 1.61; 95% CI 1.26-2.05; P<0·001) were independently associated with a shorter time to RIS. Anthracyclines and alkylating agents significantly contribute to the effect. Conclusions: This study confirms an association between chemotherapy given for the first malignancy and a shorter time to development of RIS.

Original languageEnglish
Pages (from-to)326-331
Number of pages6
JournalBritish Journal of Cancer
Issue number3
Publication statusPublished - 25 Jul 2017
Externally publishedYes

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Copyright 2017 Cancer Research UK. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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