Chiral metal complexes. 11. Steric interactions in some complexes of general form [Ru(diimine)2(S-aminoacidate)]n+

Terence J. Goodwin, Peter A. Williams*, Robert S. Vagg

*Corresponding author for this work

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A series of complexes of the type Δ,Λ-[Ru(diimine)2(S-aa)]n+ have been prepared, where diimine is 1,10-phenanthroline or 2,2′-bipyridyl and S-aa is the anion of 5-hydroxytryptophane of phenylalanine and its substituted congeners. The complexes were resolved using chromatographic methods and equilibration studies carried out at 298 K in aqueous solution to determine the position of the equilibrium {A figure is presented}. Two types of steric interaction are thought to be responsible for the chiral discriminations observed between pairs of diastereoisomers. One is that between an aromatic diimine ligand and the side chain of the coordinated amino acid. The second, evident in complexes of α-methyl-substituted S-amino acids, involves that methyl group and an amine hydrogen atom of the optically active bidentate. The α-methyl substitution results in an energetic preference for the Λ-diastereoisomer by approximately 1.6 kJ mol.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalInorganica Chimica Acta
Issue number1
Publication statusPublished - 1 Mar 1984


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