Chiral metal complexes. 50.* X-ray structure of the DNA probe Δ-α-[N,N′-dimethyl-N,N′-di(2-picolyl)-1R,2R- diaminocyclohexane]-[S-phenylalaninato(1-)]cobalt(III) perchlorate hydrate

Peter Leverett*, Janice Petherick, Peter A. Williams, Robert S. Vagg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The complex salt Δ-α-[Co(R,R-picchxnMe2)(S-phe)](ClO4) 2· H2O, where R,R-picchxnMe2 = N,N′-dimethyl-N,N′-di(2-picolyl)-1R,2R-diaminocyclohexane and S-phe is the monovalent anion of S-phenylalanine, has been prepared and its structure determined by single-crystal X-ray methods. Δ-α-[Co(R,R-picchxn Me2)(S-phe)](ClO4)2 · H2O is orthorhombic, space group P212121 with a= 10.208(1), b=16.804(1), c= 19.194(3)Å, V= 3292.5Å3, Z = 4, Dc = 1.542 and Dm= 1.49Mgm-3. The structure was refined to R = 0.046 for 3554 independent reflections with I > 2σ(I). As is the case with the R-phe analogue, the phenyl ring of the coordinated aminoacidate is not in the extended conformation, but lies adjacent to one of the pyridyl rings of the coordinated tetradentate. The attractive intramolecular π-π interaction which stabilises this conformation is analogous to that which serves to stabilise the stacking of parallel base pairs in DNA.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalJournal of Coordination Chemistry
Volume49
Issue number2
Publication statusPublished - 1999

Keywords

  • Cobalt(III)
  • DNA
  • Phenylalanine
  • Tetradentate
  • Van der waals bond
  • X-ray structure

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