Chiral metal complexes. 6. The kinetically controlled stereoselective synthesis of ternary Co(III) complexes of the type [Co(phen)2(S-aminoacidate)]n+

Jill A. Chambers, Robert D. Gillard, Peter A. Williams*, Robert S. Vagg

*Corresponding author for this work

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10 Citations (Scopus)

Abstract

The complexes Λ[Co(phen)2(aa)]2+, where aa is the singly charged anion of the α-amino acids S-glutamine, S-asparagine, S-glutamic acid and S-aspartic acid, and phen is 1,10-phenanthroline, may be synthesized stereospecifically under certain conditions by the reaction of the amino acid with Δ,Λ[Co(phen)2CO3]+. Kinetic, rather than thermodynamic, influences are responsible for the reaction products observed. It is evident that both diastereoisomers of the bis-phen complex form initially, but the rate of decomposition of the Δ-isomer is considerably faster than that of the Λ-isomer. The results have been used to reinterpret some earlier work on chiral discriminations in related complexes containing 1,2-diaminoethane, and recent results concerning the phen complexes containing glycine, S-alanine, S-phenylalanine, S-leucine, S-isoleucine and S-valine.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalInorganica Chimica Acta
Volume70
Issue numberC
DOIs
Publication statusPublished - 1983

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