Chiral metal complexes XLII. Reversed-phase high-performance liquid chromatographic separation of racemic dipeptides as their ternary Co(III) complexes with a chiral triamine

J. R. Alrich-Wright, P. D. Newman, K. R N Rao, R. S. Vagg, P. A. Williams*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The enantiomeric and diastereoisomeric dipeptides Gly-R,S-Val, Gly-R,S-Leu, Gly-R,S-Phe, R,S-Leu-Gly, R,S-Leu-R,S-Ala and R,S-Leu-R,S-Phe have been separated by RP-HPLC methods when coordinated in ternary Co(III) complexes [Co(R,R-benzet)(peptidato)]2+ [benzet = N-benzyl-N′-(2-picolyl-1,2-diaminocyclohexane)], on Amex Prepsil columns under a variety of conditions. A method is illustrated for the recovery of the pure peptides from the separated diastereoisomers. The method appears to be applicable for dipeptides, in general.

Original languageEnglish
Pages (from-to)366-370
Number of pages5
JournalJournal of Chromatography A
Volume693
Issue number2
DOIs
Publication statusPublished - 24 Feb 1995

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