Choice of capping group in tripeptide hydrogels influences viability in the three-dimensional cell culture of tumor spheroids

Jonathan P. Wojciechowski, Adam D. Martin, Alexander F. Mason, Christopher M. Fife, Sharon M. Sagnella, Maria Kavallaris, Pall Thordarson

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Two peptide‐derived low‐molecular‐weight gelators bearing different capping groups, 9‐fluorenylmethyloxycarbonyl (Fmoc) and phenothiazine, were synthesized and their gel networks were characterized. The variation of the N‐terminal capping group affects the viability of these hydrogels as a three‐dimensional cell culture for multicellular tumor spheroids. These results indicate that the phenothiazine capping group is a more biocompatible alternative to the widely used Fmoc moiety.
Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalChemPlusChem
Volume82
Issue number3
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • cytotoxicity
  • gels
  • peptides
  • self-assembly
  • tumor spheroids

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