Chromosome-Centric Human Proteome Project allies with developmental biology: a case study of the role of y chromosome genes in organ development

Anna Meyfour, Paria Pooyan, Sara Pahlavan, Mostafa Rezaei-Tavirani, Hamid Gourabi, Hossein Baharvand, Ghasem Hosseini Salekdeh

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

One of the main goals of Chromosome-Centric Human Proteome Project is to identify protein evidence for missing proteins (MPs). Here, we present a case study of the role of Y chromosome genes in organ development and how to overcome the challenges facing MPs identification by employing human pluripotent stem cell differentiation into cells of different organs yielding unprecedented biological insight into adult silenced proteins. Y chromosome is a male-specific sex chromosome which escapes meiotic recombination. From an evolutionary perspective, Y chromosome has preserved 3% of ancestral genes compared to 98% preservation of the X chromosome based on Ohno's law. Male specific region of Y chromosome (MSY) contains genes that contribute to central dogma and govern the expression of various targets throughout the genome. One of the most well-known functions of MSY genes is to decide the male-specific characteristics including sex, testis formation, and spermatogenesis, which are majorly formed by ampliconic gene families. Beyond its role in sex-specific gonad development, MSY genes in coexpression with their X counterparts, as single copy and broadly expressed genes, inhibit haplolethality and play a key role in embryogenesis. The role of X-Y related gene mutations in the development of hereditary syndromes suggests an essential contribution of sex chromosome genes to development. MSY genes, solely and independent of their X counterparts and/or in association with sex hormones, have a considerable impact on organ development. In this Review, we present major recent findings on the contribution of MSY genes to gonad formation, spermatogenesis, and the brain, heart, and kidney development and discuss how Y chromosome proteome project may exploit developmental biology to find missing proteins.

LanguageEnglish
Pages4259-4272
Number of pages14
JournalJournal of Proteome Research
Volume16
Issue number12
DOIs
Publication statusPublished - 1 Dec 2017
Externally publishedYes

Fingerprint

Developmental Biology
Human Chromosomes
Proteome
Chromosomes
Genes
Y Chromosome
Sex Chromosomes
Gonads
Spermatogenesis
Proteins
Y-Linked Genes
metsulfuron methyl
Forensic Anthropology
Pluripotent Stem Cells
Gonadal Steroid Hormones
X Chromosome
Sex Characteristics
Genetic Recombination
Embryonic Development
Testis

Keywords

  • Chromosome-Centric Human Proteome Project (C-HPP)
  • Y chromosome
  • gonad formation
  • organ development

Cite this

Meyfour, Anna ; Pooyan, Paria ; Pahlavan, Sara ; Rezaei-Tavirani, Mostafa ; Gourabi, Hamid ; Baharvand, Hossein ; Salekdeh, Ghasem Hosseini. / Chromosome-Centric Human Proteome Project allies with developmental biology : a case study of the role of y chromosome genes in organ development. In: Journal of Proteome Research. 2017 ; Vol. 16, No. 12. pp. 4259-4272.
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Chromosome-Centric Human Proteome Project allies with developmental biology : a case study of the role of y chromosome genes in organ development. / Meyfour, Anna; Pooyan, Paria; Pahlavan, Sara; Rezaei-Tavirani, Mostafa; Gourabi, Hamid; Baharvand, Hossein; Salekdeh, Ghasem Hosseini.

In: Journal of Proteome Research, Vol. 16, No. 12, 01.12.2017, p. 4259-4272.

Research output: Contribution to journalReview articleResearchpeer-review

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