Chronic kidney disease and the severity of coronary artery disease and retinal microvasculature changes: A cross-sectional study

Kevin Phan*, Cheryl Au, Paul Mitchell, Gerald Liew, Adam J H Plant, Sarah B. Wang, Joseph Chiha, Aravinda Thiagalingam, George Burlutsky, Bamini Gopinath

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Prior studies have suggested the association between incidence of coronary artery disease (CAD) with chronic kidney disease (CKD) and poor glomerular filtration function. However to the best of our knowledge, few studies have specifically assessed this relationship based on the severity of CAD as quantified using Extent and Gensini scores. Methods: Between June 2009 and January 2012, data were collected from 1,680 participants as part of the Australian Heart Eye Study (AHES) cohort. Coronary angiograms were scored according to Gensini (severity) and Extent scores. Retinal vessel calibres were measured using validated semi-automated software. Potential confounders were adjusted for using multivariate analysis. Results: There were no significant associations found between CKD status with Extent and Gensini scores for CAD severity, both unadjusted and when adjusted for confounding factors. In unadjusted analyses, a significant association between CKD and narrower retinal arteriolar diameter was observed (P=0.0072). After multivariate adjustment, the association between CKD and retinal arteriolar diameter was attenuated and was no longer significant (P=0.1466). No associations were observed between retinal venular calibre and prevalent CKD. Conclusions: The present study demonstrated no independent associations between CKD and CAD severity. These results warrant validation by future large, prospective longitudinal studies.

    Original languageEnglish
    Pages (from-to)2111-2114
    Number of pages4
    JournalJournal of Thoracic Disease
    Volume8
    Issue number8
    DOIs
    Publication statusPublished - Aug 2016

    Keywords

    • Australian Heart Eye Study (AHES)
    • Chronic kidney disease (CKD)
    • Coronary artery disease (CAD)
    • Cross-sectional study
    • Retinal microvasculature

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