Chronic pancreatitis

a path to pancreatic cancer

Andreia V. Pinho, Lorraine Chantrill, Ilse Rooman*

*Corresponding author for this work

Research output: Contribution to journalReview article

76 Citations (Scopus)

Abstract

Chronic pancreatitis predisposes to pancreatic cancer development and both diseases share a common etiology. A central role has been proposed for the digestive enzyme-secreting acinar cell that can undergo ductal metaplasia in the inflammatory environment of pancreatitis. This metaplastic change is now a recognised precursor of pancreatic cancer. Inflammatory molecules also foster tumour growth through autocrine and paracrine effects in the epithelium and the stroma.These insights have raised new opportunities such as the manipulation of inflammation as a preventive and/or therapeutic strategy for pancreatic cancer. Finally, we address the need for an in-depth study of the pancreatic acinar cells.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalCancer Letters
Volume345
Issue number2
DOIs
Publication statusPublished - 10 Apr 2014
Externally publishedYes

Keywords

  • Acinar to ductal metaplasia
  • Dedifferentiation
  • Inflammation
  • Oxidative stress
  • Pancreatic cancer
  • Pancreatitis

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