TY - JOUR
T1 - Ciprofloxacin is actively transported across bronchial lung epithelial cells using a calu-3 air interface cell model
AU - Ong, Hui Xin
AU - Traini, Daniela
AU - Bebawy, Mary
AU - Young, Paul M.
PY - 2013
Y1 - 2013
N2 - Ciprofloxacin is a well-established broad-spectrum fluoroquinolone antibiotic that penetrates well into the lung tissues; still, the mechanisms of its transepithelial transport are unknown. The contributions of specific transporters, including multidrug efflux transporters, organic cation transporters, and organic anion-transporting polypeptide transporters, to the uptake of ciprofloxacin were investigated in vitro using an air interface bronchial epithelial model. Our results demonstrate that ciprofloxacin is subject to predominantly active influx and a slight efflux component.
AB - Ciprofloxacin is a well-established broad-spectrum fluoroquinolone antibiotic that penetrates well into the lung tissues; still, the mechanisms of its transepithelial transport are unknown. The contributions of specific transporters, including multidrug efflux transporters, organic cation transporters, and organic anion-transporting polypeptide transporters, to the uptake of ciprofloxacin were investigated in vitro using an air interface bronchial epithelial model. Our results demonstrate that ciprofloxacin is subject to predominantly active influx and a slight efflux component.
UR - http://www.scopus.com/inward/record.url?scp=84877842865&partnerID=8YFLogxK
U2 - 10.1128/AAC.00306-13
DO - 10.1128/AAC.00306-13
M3 - Article
C2 - 23507281
SN - 0066-4804
VL - 57
SP - 2535
EP - 2540
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 6
ER -