Circadian rhythmicity in emerging mood disorders

state or trait marker?

Ashlee B Grierson, Ian B. Hickie, Sharon L Naismith, Daniel F. Hermens, Elizabeth M. Scott, Jan Scott

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

BACKGROUND: Circadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms. There is limited research on the role of circadian disturbances in mood disorders in young people and/or first episode cases of unipolar and bipolar disorders.

METHODS: Actigraphy was undertaken for about 14 days in 63 post-pubertal individuals aged 13-25 years with a recent onset of a mood disorder meeting recognised diagnostic criteria. We examined associations between three easily interpretable markers of circadian rhythm activity (amplitude, acrophase and rhythmicity index) and demography and clinical characteristics. Then, circadian markers were compared between diagnostic groups, controlling for potential confounders.

RESULTS: Longer duration of illness was correlated with reduced circadian rhythmicity and lower levels of activity over 24 h. A delay in the timing of maximum activity was associated with the level of manic but not depressive symptoms. The circadian rhythmicity index differentiated unipolar from bipolar cases, and in bipolar but not unipolar disorder, the rhythmicity was less robust in those with more severe manic or depressive symptoms.

CONCLUSIONS: Less robust circadian rhythmicity, especially associated with increasing symptom severity, may represent a more specific or a trait marker of young people with mood disorders who are at higher risk of a bipolar course of illness.

Original languageEnglish
Article number3
Pages (from-to)1-7
Number of pages7
JournalInternational journal of bipolar disorders
Volume4
Issue number1
DOIs
Publication statusPublished - 13 Jan 2016
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Adolescence
  • Circadian rhythm
  • Bipolar
  • Unipolar
  • Young adult
  • Trait

Fingerprint Dive into the research topics of 'Circadian rhythmicity in emerging mood disorders: state or trait marker?'. Together they form a unique fingerprint.

  • Cite this

    Grierson, A. B., Hickie, I. B., Naismith, S. L., Hermens, D. F., Scott, E. M., & Scott, J. (2016). Circadian rhythmicity in emerging mood disorders: state or trait marker? International journal of bipolar disorders, 4(1), 1-7. [3]. https://doi.org/10.1186/s40345-015-0043-z